The effects of riboflavin on ischemia/reperfusion induced renal injury: Role on caspase-3 expression

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dc.authoridUniversity, Aydin Adnan Menderes/0000-0002-9325-3757
dc.authoridYakut, Zatiye Ayça Çevikelli/0000-0002-6697-6781
dc.authoridOzbeyli, Dilek/0000-0002-4141-6913
dc.authoridŞener, Göksel/0000-0001-7444-6193
dc.authoridSener, Tarik Emre/0000-0003-0085-7680
dc.authorwosidUniversity, Aydin Adnan Menderes/Z-2790-2019
dc.authorwosidYakut, Zatiye Ayça Çevikelli/AAF-7800-2021
dc.authorwosidOzbeyli, Dilek/AAC-2498-2020
dc.authorwosidŞener, Göksel/AAN-4461-2021
dc.authorwosidErtas, Busra/IQS-8337-2023
dc.authorwosidSener, Tarik Emre/AAR-8427-2020
dc.contributor.authorAyaz Adakul, Betul
dc.contributor.authorErtas, Busra
dc.contributor.authorCevikelli, Zatiye Ayca
dc.contributor.authorOzbeyli, Dilek
dc.contributor.authorErcan, Feriha
dc.contributor.authorKandemir, Cansu
dc.contributor.authorCevik, Ozge
dc.date.accessioned2024-06-12T10:52:09Z
dc.date.available2024-06-12T10:52:09Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractReactive oxygen metabolites play important roles in ischemia/reperfusion (I/R) injury in several organ systems. Riboflavin has been shown to exert antioxidant and/or anti-inflammatory activities in several experimental models. The aim of this study was to investigate the role of riboflavin against I/R injury in the rat kidney. Wistar albino rats 200-300 g weighing were divided into 3 groups. One week after unilateral nephrectomy, the IR procedure was applied to the rats. To induce I/R injury renal pedicle was clamped for 45 minutes and then rats were allowed reperfusion for 6 hours. Riboflavin (25 mg/ kg, orally) or vehicle was administered for one week as pretreatment. After decapitation, kidney tissue samples were taken for the evaluation of malondialdehyde (MDA), an end product of lipid peroxidation; glutathione (GSH), a key antioxidant; and 8-hydroxydeoxyguanosine (8-OHdG), a specific marker of oxidative DNA damage. Furthermore, myeloperoxidase (MPO) and caspase-3 activities were also examined together with histological analysis. Ischemia/reperfusion induced significant increases in MDA and 8-OHdG levels and MPO and caspase- 3 activities, and decrese in GSH levels. In the riboflavin treatment these indices were found to be reversed back to control levels. The present data demonstrated that riboflavin, through its antioxidant effect, attenuates I/R induced acute renal injury in rats.en_US
dc.identifier.doi10.12991/jrp.2019.145
dc.identifier.endpage386en_US
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85066927818en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage379en_US
dc.identifier.trdizinid357482en_US
dc.identifier.urihttps://doi.org/10.12991/jrp.2019.145
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/357482
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18595
dc.identifier.volume23en_US
dc.identifier.wosWOS:000468157000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal Of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectIschemia Reperfusionen_US
dc.subjectRiboflavinen_US
dc.subjectCaspaseen_US
dc.subjectAbdominal Aortic-Aneurysmen_US
dc.subjectVitamin B-2en_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.subjectReperfusionen_US
dc.subjectIschemiaen_US
dc.subjectMelatoninen_US
dc.subjectMyeloperoxidaseen_US
dc.titleThe effects of riboflavin on ischemia/reperfusion induced renal injury: Role on caspase-3 expressionen_US
dc.typeArticleen_US

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