A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

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dc.authoridKrazinski, Bartlomiej Emil/0000-0002-3537-4710
dc.authoridGelisgen, Remise/0000-0003-4121-5107
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authorwosidKrazinski, Bartlomiej Emil/G-9073-2011
dc.authorwosidGelisgen, Remise/D-2983-2019
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorDereli, Murat
dc.contributor.authorKrazinski, Bartlomiej E.
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorAksu, Burhan
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUzun, Hafize
dc.contributor.authorGelisgen, Remise
dc.date.accessioned2024-06-12T10:58:38Z
dc.date.available2024-06-12T10:58:38Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAccidentally ingested corrosive substances can cause functional and structural damage to the esophageal tissue resulting in stricture formation. It has been reported that the administration of olmesartan (OLM) can have anti-inflammatory, antifibrotic and antiapoptotic effects on injured tissue. The aim of our study was to check if OLM could prevent formation of scars in the corrosive esophageal burn model. Fifty-one Wistar Albino rats were divided into six groups: Control, Sham, OLM, Sham + OLM, Burn, and Burn + OLM. Olmesartan (5 mg/kg) was given by gavage once per day for 21 consecutive days after injury. The morphology of the esophagus was assessed after Masson trichrome staining, and apoptosis was evaluated using the terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) method. The serum nucleosomes (as an indicator of apoptosis), serum p53 protein, and esophageal tissue p53 protein levels of each group were measured by immunoassays. Muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in the Burn + OLM group decreased significantly compared with the Burn group (p < 0.05). Similarly, the number of apoptotic cells in the Burn + OLM group decreased compared with the Burn group (p < 0.05). Serum levels of nucleosomes and p53 and tissue of p53 protein did not differ between the groups. Exogenously administered OLM can effectively prevent the occurrence of esophageal strictures caused by corrosive esophageal burns.en_US
dc.description.sponsorshipProject TUBAB by Trakya University Research Center, Edirne, Turkeyen_US
dc.description.sponsorshipThis study was supported as a Project TUBAB by Trakya University Research Center, Edirne, Turkey.en_US
dc.identifier.doi10.5603/FHC.2014.0003
dc.identifier.endpage35en_US
dc.identifier.issn0239-8508
dc.identifier.issn1897-5631
dc.identifier.issue1en_US
dc.identifier.pmid24802958en_US
dc.identifier.scopus2-s2.0-84900037217en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.5603/FHC.2014.0003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20142
dc.identifier.volume52en_US
dc.identifier.wosWOS:000335969500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Histochemica Et Cytobiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorrosive Esophageal Burnen_US
dc.subjectStrictureen_US
dc.subjectOlmesartanen_US
dc.subjectProtectionen_US
dc.subjectApoptosisen_US
dc.subjectTUNELen_US
dc.subjectNucleosomesen_US
dc.subjectP53en_US
dc.subjectCollagen-Synthesisen_US
dc.subjectOxidative Stressen_US
dc.subjectInjuryen_US
dc.subjectFibrosisen_US
dc.subjectBurnsen_US
dc.subjectTherapyen_US
dc.subjectHypertensionen_US
dc.subjectAntioxidanten_US
dc.subjectSuppressionen_US
dc.subjectInhibitionen_US
dc.titleA novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosisen_US
dc.typeArticleen_US

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