IgD attenuates the IgM-induced anergy response in transitional and mature B cells

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dc.authoridEnders, Anselm/0000-0001-5933-6463
dc.authoridGoodnow, Christopher C/0000-0001-5296-6155
dc.authoridYabas, Mehmet/0000-0002-3462-5389
dc.authoridHumburg, Peter/0000-0002-3331-6496
dc.authoridField, Matt/0000-0003-0788-6513
dc.authoridAndrews, Dan/0000-0003-3922-6376
dc.authoridHorikawa, Keisuke/0000-0002-7381-9450
dc.authorwosidEnders, Anselm/B-1165-2011
dc.authorwosidAndrews, Dan/ABG-4815-2020
dc.authorwosidGoodnow, Christopher C/V-8108-2018
dc.authorwosidYabas, Mehmet/D-9513-2012
dc.authorwosidHorikawa, Keisuke/N-4417-2019
dc.authorwosidHumburg, Peter/A-4191-2009
dc.contributor.authorSabouri, Zahra
dc.contributor.authorPerotti, Samuel
dc.contributor.authorSpierings, Emily
dc.contributor.authorHumburg, Peter
dc.contributor.authorYabas, Mehmet
dc.contributor.authorBergmann, Hannes
dc.contributor.authorHorikawa, Keisuke
dc.date.accessioned2024-06-12T11:17:35Z
dc.date.available2024-06-12T11:17:35Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSelf-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. Here we define the RNA landscape of the in vivo anergy response, comprising 220 induced sequences including a core set of 97. Failure to co-express IgD with IgM decreases overall expression of receptors for self-antigen, but paradoxically increases the core anergy response, exemplified by increased Sdc1 encoding the cell surface marker syndecan-1. IgD expressed on its own is nevertheless competent to induce calcium signalling and the core anergy mRNA response. Syndecan-1 induction correlates with reduction of surface IgM and is exaggerated without surface IgD in many transitional and mature B cells. These results show that IgD attenuates the response to self-antigen in anergic cells and promotes their accumulation. In this way, IgD minimizes tolerance-induced holes in the pre-immune antibody repertoire.en_US
dc.description.sponsorshipNIH [U19 AI100627]; NHMRC [585490, 1016953, 1081858]; NHMRC CJ Martin Fellowship [595989]; Australian Government; National Collaborative Research Infrastructure Scheme Australian Phenomics Facility; National Health and Medical Research Council of Australia [1081858] Funding Source: NHMRCen_US
dc.description.sponsorshipThis work was supported by NIH grant U19 AI100627 and NHMRC grants 585490, 1016953 and 1081858 to C.C.G., NHMRC CJ Martin Fellowship 595989 to J.H.R., an Endeavour Award from the Australian Government to Z.S. and the National Collaborative Research Infrastructure Scheme Australian Phenomics Facility.en_US
dc.identifier.doi10.1038/ncomms13381
dc.identifier.issn2041-1723
dc.identifier.pmid27830696en_US
dc.identifier.scopus2-s2.0-84994810744en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/ncomms13381
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24770
dc.identifier.volume7en_US
dc.identifier.wosWOS:000387348700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntigen Receptor Complexen_US
dc.subjectImmunoglobulin-Den_US
dc.subjectSurface Igmen_US
dc.subjectSelf-Toleranceen_US
dc.subjectTransgenic Miceen_US
dc.subjectBone-Marrowen_US
dc.subjectLymphocytesen_US
dc.subjectExpressionen_US
dc.subjectActivationen_US
dc.subjectInductionen_US
dc.titleIgD attenuates the IgM-induced anergy response in transitional and mature B cellsen_US
dc.typeArticleen_US

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