The clearance time of infused hematopoietic stem cell from the blood circulation

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dc.contributor.authorDonmez, Ayhan
dc.contributor.authorOzsan, Fatma
dc.contributor.authorArik, Bahar
dc.contributor.authorOzkayin, Nese
dc.contributor.authorCagirgan, Seckin
dc.contributor.authorMir, Sevgi
dc.contributor.authorVural, Filiz
dc.date.accessioned2024-06-12T10:55:58Z
dc.date.available2024-06-12T10:55:58Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThere is no detailed information about the clearance time of infused hematopoietic stem cell (HSC) from the blood circulation in humans. In this prospective study, peripheral blood CD34+ cell counts were detected during the 4 days period following autologous HSC transplantation in 20 patients by means of flow cytometry. The median CD34+ cells were at the highest level in the first hour and decreased below pre-infusion values on the first day after HSC infusion. By nonparametric analysis, positive correlation was found between CD34+ cell levels at the first hour and the post-thaw CD34+ cell dose (r = 0.57, p = 0.01). An inverse correlation was determined between CD34+ cell levels at the first hour and neutrophil engraftment (r = -0.54, p = 0.01). Compared with the patients having CD34+ cell count of >= 2 mu L-1 in the first hour following HSC infusion, the patients having CD34+ cell count of <2 mu L-1 had delayed both neutrophil (20 vs. 12, p = 0.008) and platelet (47 vs. 11, p = 0.01) engraftments. Our results indicated that infused HSCs were removed from the blood circulation within 1 day. In addition, CD34+ cell levels at the first hour may be used as an important indicator to predict the delay of neutrophil and platelet engraftments. (c) 2013 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipEge University Research Foundation [2005-TIP-030]; Ege University Research Ethics Committee [06-8/17]; Ege University Grand [2005-TIP-030]en_US
dc.description.sponsorshipThis study was supported by Ege University Research Foundation (2005-TIP-030, Ege University Research Ethics Committee Decision Number: 06-8/17).; This project was supported by Ege University Grand (2005-TIP-030).en_US
dc.identifier.doi10.1016/j.transci.2013.01.005
dc.identifier.endpage239en_US
dc.identifier.issn1473-0502
dc.identifier.issue2en_US
dc.identifier.pmid23428427en_US
dc.identifier.scopus2-s2.0-84877632667en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2013.01.005
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19622
dc.identifier.volume48en_US
dc.identifier.wosWOS:000319538300046en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion And Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD34+Cell Levelsen_US
dc.subjectEngraftmenten_US
dc.subjectHomingen_US
dc.subjectStem Cell Transplantationen_US
dc.subjectProgenitor Cellsen_US
dc.subjectTraffickingen_US
dc.subjectEngraftmenten_US
dc.titleThe clearance time of infused hematopoietic stem cell from the blood circulationen_US
dc.typeArticleen_US

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