The effect of high-fructose feeding on hemodynamic behavior and infarct size of isolated rat hearts subjected to low-flow ischemia.

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dc.contributor.authorÖzen, Serap Topçu
dc.contributor.authorPalabıyık, Orkide
dc.contributor.authorGuksu, Zuhal
dc.contributor.authorAslan, Enver
dc.contributor.authorTosunoğlu, Esra Akbaş
dc.contributor.authorSüt, Necdet
dc.contributor.authorVardar, Selma Arzu
dc.date.accessioned2024-06-12T10:05:37Z
dc.date.available2024-06-12T10:05:37Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate the potentially deleterious effect of in vivo high-fructose feeding of rats on ex vivo hemodynamic recovery and infarct size of isolated rat hearts subjected to low-flow ischemia and reperfusion. Methods: After feeding Sprague-Dawley male rats with a high-fructose (n=9), high-glucose (n=9), or a standard diet (n=9) for four weeks, the hearts were extirpated and perfused ex vivo with a Krebs-Henseleit solution for 15 minutes; after that, the hearts were subjected to low-flow (0.3 ml/ minute) ischemia during 30 minutes followed by 60 minutes reperfusion. Left developed ventricular pressure, maximum and minimum rate changes of left ventricular pressure, and heart rate were recorded before ischemia and after reperfusion. The Infarct area was measured at the end of the reperfusion period. Results: The relative myocardial infarct size did not differ between the three groups in isolated hearts subjected to ex vivo low-flow ischemia followed by 60 minutes of reperfusion. Post-ischemic cardiac contractile recovery appeared complete in the high-fructose and high-glucose groups at 60 minutes of reperfusion. In contrast, the left developed ventricular pressure and minimum rate change of left ventricular pressure were still depressed at the end of 60 minutes of reperfusion in the control group. Conclusion: High-fructose diet in rats appears to positively affect the recovery of left ventricular contractile function after low-flow ischemia, compared to a standard diet, without a difference in relative myocardial infarct size. Similar results were obtained in the high-glucose-fed rats.en_US
dc.identifier.doi10.54005/geneltip.1095947
dc.identifier.endpage329en_US
dc.identifier.issn2602-3741
dc.identifier.issue3en_US
dc.identifier.startpage324en_US
dc.identifier.trdizinid1107967en_US]
dc.identifier.urihttps://doi.org/10.54005/geneltip.1095947
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1107967
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13531
dc.identifier.volume32en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofGenel Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effect of high-fructose feeding on hemodynamic behavior and infarct size of isolated rat hearts subjected to low-flow ischemia.en_US
dc.typeArticleen_US

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