THE INTERACTION OF RADIOTHERAPY AND CHEMOTHERAPY IN BREAST CANCER TREATMENT

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dc.contributor.authorTokatli, Fusun
dc.date.accessioned2024-06-12T10:55:11Z
dc.date.available2024-06-12T10:55:11Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCytotoxic agents can increase the efficacy of radiation. Radiosensitizing effects (interaction within the radiation field) can be additive or supra-additive. Multiple mechanisms underlie radiosensitizing properties of cytotoxic agents and include increased radiation damage, inhibition of DNA repair, cell-cycle synchronization, increased cytotoxicity against hypoxic cells, inhibition of prosurvival pathways, and abrogation of rapid tumor cell repopulation. The agents, which have the most radiosensitizing effects, are cisplatin and paclitaxel. In addition to the classic cytotoxic agents with radiosensitizing properties several novel agents show promising interactions with radiation (e.g. EGFR inhibitors, antiangiogenic agents). Today, a sequential treatment is the standard treatment in the early stage breast cancer patients. However, concomitant chemotherapy and radiotherapy (RT) could be more appropriate to patients with high risk of recurrence, for example, in those with axillary lymph node metastases, close or positive surgical margins, large tumor size, young age and presence of lymphovascular invasion. Phase III trials are needed to define the benefits and the late effects of concomitant modern RT techniques (with 3 dimensional conformal, intensity modulated or image guided RT) with taxanes, capecitabine and targeted biologic agents in the adjuvant settings.en_US
dc.identifier.endpage76en_US
dc.identifier.issn2149-1976
dc.identifier.issue2en_US
dc.identifier.startpage70en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19330
dc.identifier.volume4en_US
dc.identifier.wosWOS:000218501800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofJournal Of Breast Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectConcomitant Therapyen_US
dc.subjectRadiosensitizing Effecten_US
dc.subjectRadio-Therapyen_US
dc.subjectChemotherapyen_US
dc.titleTHE INTERACTION OF RADIOTHERAPY AND CHEMOTHERAPY IN BREAST CANCER TREATMENTen_US
dc.typeReview Articleen_US

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