Antiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.contributor.authorAktas, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorKocak, Zafer
dc.date.accessioned2024-06-12T11:04:00Z
dc.date.available2024-06-12T11:04:00Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the antiapoptotic and proliferative activity of curcumin (Cur) on the ovarian follicles in mice exposed to whole body ionizing radiation (Rd). The mice were exposed to 8.3 gray whole body Rd, and Cur groups were given as a daily dose of 100 mg/kg of Cur for 10 days (10 days before Rd). The ovaries were collected 3 and 12 h after irradiation. To date, no such studies have been performed on antiapoptotic and proliferative activity of Cur on the ovarian follicles in mice exposed to whole body Rd. Analysis of mice ovary after exposure to Rd by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling showed that there were apoptotic cells both in the follicular wall and the antrum, and that the number of follicles showing early atresic features was high 3 h after Rd. On the other hand, analysis of mice ovary 12 h after exposure to Rd showed that the number of follicles containing apoptotic cells with advanced atresic features was significantly higher when compared to the 3-h Rd exposure group. The proliferating cell nuclear antigen-positive granulosa cells were decreased in association with follicular atresia. The groups given treatment were observed to have some benefit from Cur against the damage caused by Rd. The results of this study demonstrate that Cur prevents follicular atresia in Rd-induced apoptosis in ovarian follicles.en_US
dc.identifier.doi10.1177/0748233711425080
dc.identifier.endpage863en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9en_US
dc.identifier.pmid22075690en_US
dc.identifier.scopus2-s2.0-84866348044en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage852en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711425080
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21874
dc.identifier.volume28en_US
dc.identifier.wosWOS:000308886000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIonizing Radiationen_US
dc.subjectOvarian Folliclesen_US
dc.subjectApoptosisen_US
dc.subjectTUNELen_US
dc.subjectPCNAen_US
dc.subjectMiceen_US
dc.subjectFollicular Developmenten_US
dc.subjectMouse Ovaryen_US
dc.subjectApoptosisen_US
dc.subjectAtresiaen_US
dc.subjectRaten_US
dc.subjectRadioprotectionen_US
dc.subjectDegenerationen_US
dc.subjectMechanismsen_US
dc.subjectExpressionen_US
dc.subjectTherapyen_US
dc.titleAntiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiationen_US
dc.typeArticleen_US

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