The effect of melatonin on protein oxidation and nitric oxide in the brain tissue of hypoxic neonatal rats

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dc.authoridbasaran, umit nusret/0000-0002-9977-6655
dc.authoridTutunculer, Filiz/0000-0003-3710-288X
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorTutunculer, Filiz
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorTaskiran, Ali
dc.contributor.authorCakir, Erol
dc.date.accessioned2024-06-12T11:08:14Z
dc.date.available2024-06-12T11:08:14Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMelatonin is a potent antioxidant agent that can scavenge oxy- and nitroradicals generated under hypoxic conditions in the brain. In this study, we investigated the effect of melatonin on protein oxidation and nitric oxide (NO) during hypoxia. Seven-day-old Sprague-Dawley newborn rats were divided into three groups. Hypoxic (n = 9) and melatonin (n = 11) groups were subjected to 2 h of hypoxic exposure (a humidity mixture of gases consisting of 92% nitrogen and 8% oxygen). Melatonin (at a dose of 10 mg/kg) was administrated 30 min before the onset hypoxia and then at 24th and 48th hours after the end of the hypoxic exposure. Control (n = 10) and hypoxic groups received the isotonic sodium chloride according to the same schedule. The brain tissue concentration of advanced oxidation protein products (AOPP) and protein thiol (P-SH) was used as an index of protein oxidation. In our study, although AOPP and NO increased significantly, the levels of P-SH decreased in the hypoxic group. The level of AOPP was declined by melatonin treatment. However, perturbed thiol status could not be recovered by melatonin treatment. There was no relationship between the levels of NO and protein oxidation markers. These results indicate that exogenous melatonin could prevent AOPP, but that it is inadequate in recovering perturbed thiol status. Therefore, melatonin alone was observed to be an incomplete treatment to prevent protein oxidation in hypoxia-induced brain damage. (c) 2006 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.braindev.2006.05.007
dc.identifier.endpage24en_US
dc.identifier.issn0387-7604
dc.identifier.issn1872-7131
dc.identifier.issue1en_US
dc.identifier.pmid16843629en_US
dc.identifier.scopus2-s2.0-33846043053en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.1016/j.braindev.2006.05.007
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22362
dc.identifier.volume29en_US
dc.identifier.wosWOS:000244128800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain & Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectHypoxiaen_US
dc.subjectAdvanced Protein Oxidation Producten_US
dc.subjectTotal Thiolen_US
dc.subjectNonprotein Thiolen_US
dc.subjectProtein Thiol And Nitric Oxideen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectSynthase Activityen_US
dc.subjectReactive Oxygenen_US
dc.subjectFree-Radicalsen_US
dc.subjectMechanismsen_US
dc.subjectInjuryen_US
dc.subjectInhibitionen_US
dc.subjectStressen_US
dc.subjectDamageen_US
dc.subjectReductionen_US
dc.titleThe effect of melatonin on protein oxidation and nitric oxide in the brain tissue of hypoxic neonatal ratsen_US
dc.typeArticleen_US

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