The role of n-acetylcysteine in lower extremity ischemia/reperfusion

dc.contributor.authorEge, T.
dc.contributor.authorEskiocak, S.
dc.contributor.authorEdis, M.
dc.contributor.authorDuran, E.
dc.date.accessioned2024-06-12T11:07:17Z
dc.date.available2024-06-12T11:07:17Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim. To evaluate the efficacy of N-acetyl cysteine (NAC) in lower extremity ischemia/reperfusion. Methods. A total of 23 patients who underwent surgical intervention due to acute femoral artery occlusion were assigned into 2 groups: control group (group 1, n=12); and NAC group (group 2, n=11). Patients in NAC group received NAC before reperfusion, and 8 and 16 h after reperfusion (3x300 mg), while patients in control group received only NaCl 0.9% (3x100 ML). Catalase, malondialdehyde (MDA) and thiol concentrations were determined in femoral vein samples collected at 6 different time points: before reperfusion (t(1)), and 30 min (t(2)), 2 h (t(3)), 6 h (t(4)), 12 h (t(5)) and 24 h (t(6)) after reperfusion. Alveolar-arterial oxygen gradient (A-aO(2)) was calculated in radial artery blood samples simultaneously collected at the same time points. Results. No significant differences between the two groups with regard to age (control group 61 +/- 13 and NAC group 64 +/- 11 years), gender (control group M/F: 7/5, NAC 6/5) and the average time from onset of symptoms (control group 9.6 +/- 3.5 h, and NAC group 10.2 +/- 3.1 h) were present. Catalase enzyme activity increased with reperfusion in both groups and there were no differences between the two groups. MDA levels did not change significantly with reperfusion in NAC group, whereas they were significantly higher in control group at t2 and t3 compared to NAC group (P<0.05). Thiol concentrations decreased with reperfusion in control group, and in NAC group increases that started with reperfusion returned back to baseline levels after 24 hours. Although the A-aO(2) gradient increased in both groups with the beginning of reperfusion, the most prominent increase occurred in control group (P<0.05). Conclusion. In control group, the significant increase in MDA levels and A-aO(2) gradient in reperfusion phase were considered a sign of local and end organ injury. We did not observe these changes in NAC performed group thus showing the efficacy of NAC.en_US
dc.identifier.endpage568en_US
dc.identifier.issn0021-9509
dc.identifier.issn1827-191X
dc.identifier.issue5en_US
dc.identifier.pmid17033604en_US
dc.identifier.scopus2-s2.0-33750688880en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage563en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21980
dc.identifier.volume47en_US
dc.identifier.wosWOS:000241757300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofJournal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia Reperfusionen_US
dc.subjectN-Acetyl Cysteineen_US
dc.subjectMalondialdehydeen_US
dc.subjectThiolen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectNitric-Oxideen_US
dc.subjectGlutathioneen_US
dc.subjectLeukosequestrationen_US
dc.subjectPathophysiologyen_US
dc.subjectCatalaseen_US
dc.subjectAciden_US
dc.titleThe role of n-acetylcysteine in lower extremity ischemia/reperfusionen_US
dc.typeArticleen_US

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