Descending serotonergic and noradrenergic systems do not regulate the antipruritic effects of cannabinoids

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dc.authoridtodurga seven, zeynep gizem/0000-0002-2529-0118
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidtodurga seven, zeynep gizem/AAB-7657-2020
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorTodurga, Zeynep Gizem
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:55:36Z
dc.date.available2024-06-12T10:55:36Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: For centuries, cannabinoids have been known to be effective in pain states. Itch and pain are two sensations sharing a lot in common. Objective: The goal of this research was to observe whether the cannabinoid agonist WIN 55,212-2 reduces serotonin-induced scratching behaviour and whether neurotoxic destruction of descending serotonergic and noradrenergic pathways mediate the antipruritic effect of WIN 55,212-2. Material and methods: Scratching behaviour was induced by intradermal injection of serotonin (50 mu g/50 mu l/mouse) to Balb/c mice. The neurotoxins 5,7-dihydroxytryptamine (5,7-DHT, 50 mu g/mouse) and 6-hydroxydopamine (6-OHDA, 20 mu g/mouse) are applied intrathecally to deplete serotonin and noradrenaline in the spinal cord. WIN 55,212-2 (1, 3, 10 mg/kg, i.p.) dose-dependently attenuated serotonin-induced scratches. Neurotoxic destruction of neither the serotonergic nor the noradrenergic systems by 5,7-DHT and 6-OHDA, respectively, had any effect on the antipruritic action of WIN 55,212-2. Conclusion: Our findings indicate that cannabinoids dose-dependently reduce serotonin-induced scratching behaviour and neurotoxic destruction of descending inhibitory pathways does not mediate this antipruritic effect.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2013/44]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP-2013/44).en_US
dc.identifier.doi10.1017/neu.2016.16
dc.identifier.endpage326en_US
dc.identifier.issn1601-5215
dc.identifier.issue6en_US
dc.identifier.pmid27805543en_US
dc.identifier.scopus2-s2.0-85006307242en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2016.16
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19485
dc.identifier.volume28en_US
dc.identifier.wosWOS:000387823800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCannabinoid Systemen_US
dc.subjectDescending Inhibitionen_US
dc.subjectWIN 55,212-2en_US
dc.subjectPruritusen_US
dc.subjectSpinal 5-Ht7 Receptorsen_US
dc.subjectItch-Related Responsesen_US
dc.subjectEndocannabinoid Modulationen_US
dc.subjectTherapeutic Targeten_US
dc.subjectMiceen_US
dc.subjectPathwaysen_US
dc.subjectPainen_US
dc.subjectActivationen_US
dc.subjectCb1en_US
dc.subjectAntinociceptionen_US
dc.titleDescending serotonergic and noradrenergic systems do not regulate the antipruritic effects of cannabinoidsen_US
dc.typeArticleen_US

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