Effects of Selective Serotonin Reuptake Inhibitors on Macular Ganglion Cell Complex Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness

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dc.authoridGüçlü, Hande/0000-0002-3021-0493
dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorid, Rugül/0000-0003-2596-0473;
dc.authorwosidCaliyurt, Okan/ABE-7339-2020
dc.authorwosidGüçlü, Hande/AAW-9756-2020
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.authorwosidOzal, Sadık Altan/B-5123-2019
dc.authorwosid, Rugül/AAI-1711-2019
dc.authorwosidçınar, rugül köse/S-8927-2019
dc.contributor.authorGuclu, Hande
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorGurlu, Vuslat Pelitli
dc.contributor.authorCinar, Rugul Kose
dc.contributor.authorOzal, Sadik Altan
dc.contributor.authorCaliyurt, Okan
dc.date.accessioned2024-06-12T11:07:58Z
dc.date.available2024-06-12T11:07:58Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs.Methods: The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients underwent a full ophthalmological examination in which macular thickness, GCC thickness, and peripapillary RNFL thickness were measured using optical coherence tomography (OCT). The Mann-Whitney U test was used to compare the patients' group with the age- and gender-matched control group. Pearson correlation analyses were also performed to assess the relationships between macular thickness, GCC thickness, RNFL thickness, and the duration of SSRI usage.Results: The mean duration of SSRI usage was 29.9627.19 (range 6-120) months. The foveal thickness was 253.48 +/- 22.77 mu m in the patients' group and 266.60 +/- 20.64 mu m in the control group; the difference between the groups was statistically significant. In addition, the perifoveal GCC thickness in the inferonasal and inferotemporal quadrant were significantly smaller thinner in the patient group (Mann-Whitney U test, p=0.021and p=0.013, respectively).Conclusions: Our results suggest a relation between SSRIs and decreased retinal GCC thickness and RNFL thickness. Future long-term prospective studies should elucidate the actual effect of SSRIs on GCC and RNFL thickness.en_US
dc.identifier.doi10.1080/02713683.2017.1420198
dc.identifier.endpage552en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue4en_US
dc.identifier.pmid29283680en_US
dc.identifier.scopus2-s2.0-85039545400en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage547en_US
dc.identifier.urihttps://doi.org/10.1080/02713683.2017.1420198
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22260
dc.identifier.volume43en_US
dc.identifier.wosWOS:000427552000018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMacular Thicknessen_US
dc.subjectGanglion Cell Complex Thicknessen_US
dc.subjectRetinal Nerve Fiber Layer Thicknessen_US
dc.subjectSelective Serotonin Reuptake Inhibitorsen_US
dc.subjectAngle-Closure Glaucomaen_US
dc.subjectOptical Coherence Tomographyen_US
dc.subjectMajor Depressive Disorderen_US
dc.subjectFluoxetineen_US
dc.subjectParoxetineen_US
dc.subjectRetinopathyen_US
dc.subjectPatienten_US
dc.subjectAntidepressantsen_US
dc.subjectChloroquineen_US
dc.subjectCitalopramen_US
dc.titleEffects of Selective Serotonin Reuptake Inhibitors on Macular Ganglion Cell Complex Thickness and Peripapillary Retinal Nerve Fiber Layer Thicknessen_US
dc.typeArticleen_US

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