Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: A pilot study

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dc.contributor.authorMemis, Dilek
dc.contributor.authorKargi, M.
dc.contributor.authorSut, N.
dc.date.accessioned2024-06-12T10:59:23Z
dc.date.available2024-06-12T10:59:23Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: We aimed to select the sedative drug with the least impact on hepatic blood flow in sedation-administered patients. In our study, we aimed to establish whether deximedetomidine and propofol affect liver function during early septic shock. The hepatic blood flow is evaluated by the transcutaneous assessment of indocyanine green plasma disappearance rate (ICG-PDR) in critically ill patients. Methods: Forty early septic shock patients were included in the study and administered either the loading dose infusion of propofol (n = 20, group P) of 1 mg/kg over 15 minutes followed by a maintenance dose of I to 3 mg/kg per hour (n = 20, group P), or a loading dose of dexmedetomidine 1 mu g/kg over 10 minutes followed by a maintenance of 0.2 to 2.5 mu g/kg per hour (n = 20, group D) (24-hour infusion). Indocyanine green (ICG) elimination tests were conducted concurrently using the noninvasive liver function monitoring system (LiMON; Pulsion Medical Systems, Munich, Germany). A dose of 0.3 mg/kg of ICG was given through a cubital fossa vein as a bolus and immediately flushed with 10 mL of normal saline. We Calculated ICG-PDR. Indocyanine green plasma disappearance rate measurements were obtained at baseline (before start of the propofol or dexmedetomidine infusion) and were repeated at the 24th hour. Biochemical and hemodynamic parameters and ICG-PDR were recorded before start of the study and at 24th hour. Results: Biochemical and hemodynamic parameters did not differ significantly between the groups (P<.05). Baseline ICG-PDR levels of group P compared to group D were 24.7 +/- 14.4 vs 21.2 +/- 10.7, respectively, and after the study, ICG-PDR levels (26.5 +/- 13.7 vs 23.7 +/- 12.4) did not differ in groups (P > .05). When we examined ICG-PDR changes between groups before and after administration, there was no significant difference (P > .05). Conclusion: In our study, we found that neither propofol nor dexmedetomidine infusion affected hepatic blood flow. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jcrc.2008.10.005
dc.identifier.endpage608en_US
dc.identifier.issn0883-9441
dc.identifier.issue4en_US
dc.identifier.pmid19931154en_US
dc.identifier.scopus2-s2.0-70449492722en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2008.10.005
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20427
dc.identifier.volume24en_US
dc.identifier.wosWOS:000272404200021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectPropofolen_US
dc.subjectSeptic Shocken_US
dc.subjectIndocyanine Green Plasma Disappearance Rateen_US
dc.subjectPlasma Disappearance Rateen_US
dc.subjectEnd-Expiratory Pressureen_US
dc.subjectCritically-Ill Patientsen_US
dc.subjectPulse Dye-Densitometryen_US
dc.subjectRegional Blood-Flowen_US
dc.subjectHepatic-Dysfunctionen_US
dc.subjectCirrhotic-Patientsen_US
dc.subjectOxygen-Transporten_US
dc.subjectHemodynamicsen_US
dc.subjectVentilationen_US
dc.titleEffects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: A pilot studyen_US
dc.typeArticleen_US

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