Role of testosterone to estradiol ratio in predicting the efficacy of recombinant human chorionic gonadotropin and testosterone treatment in male hypogonadism

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dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authoridBAŞ, SÜLEYMAN/0000-0002-5883-445X
dc.authoridOzcelik, Serhat/0000-0002-0521-5866
dc.authoridOzcelik, Melike/0000-0003-0406-715X
dc.authorwosidCelik, Mehmet/AAA-8773-2021
dc.authorwosidBAŞ, SÜLEYMAN/JDV-8947-2023
dc.contributor.authorCelik, Mehmet
dc.contributor.authorOzcelik, Serhat
dc.contributor.authorBas, Suleyman
dc.contributor.authorSariaydin, Mehmet
dc.contributor.authorOzcelik, Melike
dc.contributor.authorGozu, Hulya
dc.date.accessioned2024-06-12T11:03:37Z
dc.date.available2024-06-12T11:03:37Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the role of testosterone to estradiol ratio in predicting the effectiveness of human chorionic gonadotropin and testosterone treatments in male hypogonadism. Materials and methods:Thirty-six male patients with hypogonadotropic hypogonadism were included in the study. Seventeen (47.2%) patients received weekly recombinant human choriogonadotropin alpha (hCG) treatment (group-1) and 19 (52.8%) received testosterone replacement therapy (T treatment) every 21 days (group-2). Under these treatments, adequate frequency of morning erection (0_3/week), testosterone to estradiol ratio (T/E), and testicular volume changes were analyzed. Results: The mean age of the patients was 28.5 +/- 8.7 years. When the frequency of morning erection (0_3/week) was specified as adequate, the cut-off value for effective T/E ratio was found to be 12.0 (sensitivity 93.8%, specificity 90.0%). There was no significant difference between the treatment groups in terms of total testosterone levels, T/E ratio, or frequency of morning erections (0_3/week) (p 0.05). However, there was a statistically significant difference between the groups in terms of median left-right testicular volume in favor of group-1 (p < 0,05). Conclusion: In patients with hypogonadism who are under treatment, elevated estradiol-induced erectile dysfunction symptoms may persist even if serum testosterone levels are normal. Testosterone to estradiol ratio can be used as a predictive value in the effective treatment of hypogonadotropic hypogonadism with hCG and T. Arch Endocrinol Metab. 2021;65(5):617-24en_US
dc.identifier.doi10.20945/2359-3997000000399
dc.identifier.endpage624en_US
dc.identifier.issn2359-3997
dc.identifier.issn2359-4292
dc.identifier.issue5en_US
dc.identifier.pmid34591405en_US
dc.identifier.scopus2-s2.0-85121942754en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://doi.org/10.20945/2359-3997000000399
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21720
dc.identifier.volume65en_US
dc.identifier.wosWOS:000719462000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologiaen_US
dc.relation.ispartofArchives Of Endocrinology Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypogonadismen_US
dc.subjectTestosterone To Estradiol Ratioen_US
dc.subjectMorning Erectionen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectHypogonadotropic Hypogonadismen_US
dc.subjectPenile Tumescenceen_US
dc.subjectMenen_US
dc.subjectDiagnosisen_US
dc.subjectTherapyen_US
dc.subjectHormoneen_US
dc.titleRole of testosterone to estradiol ratio in predicting the efficacy of recombinant human chorionic gonadotropin and testosterone treatment in male hypogonadismen_US
dc.typeArticleen_US

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