Role of JNK, TGF-?1, Akt, IL-1? and INSL-3 in proanthocyanidin protection against apoptosis in diabetic rat testis

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dc.authoridBayram, Sinasi/0000-0003-4785-4751
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridErsoy, Onur/0000-0001-9829-7903
dc.authorwosidBayram, Sinasi/AAK-7568-2021
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidErsoy, Onur/AAZ-5121-2020
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorBayram, Sinasi
dc.contributor.authorErsoy, Onur
dc.contributor.authorCerkezkayabekir, Aysegul
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorKaraca, Turan
dc.date.accessioned2024-06-12T10:51:06Z
dc.date.available2024-06-12T10:51:06Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated how proanthocyanidin treatment altered c-Jun N-terminal kinases, transforming growth factor beta 1, serine/threonine-specific protein kinase, interleukin 1 beta and insulin-like 3 expression in the testis of diabetic rats. We used 24 Wistar albino male rats divided into four groups. Group 1 was untreated control. Group 2 was treated with 40 mg/kg streptozotocin (STZ) for 5 days. Group 3 was treated with 40 mg/kg STZ + 250 mg/kg proanthocyanidin once daily for six weeks. Group 4 was treated with 40 mg/kg STZ + 250 mg/kg proanthocyanidin. Superoxide dismutase activity was reduced in groups 3 and 4 compared to group 2. Glutathione peroxidase activity was increased significantly in groups 3 and 4 compared to groups 1 and 2. Catalase activity was decreased in group 4 compared to group 2. We found that proanthocyanidin increased cell proliferation in diabetic testis. Phospho-JNK and TGF-beta 1 immunostaining was decreased groups 3 and 4 compared to group 2, while p-Akt immunostaining was increased in groups 3 and 4. The number of IL-1 beta immunostained cells in groups 3 and 4 was decreased compared to group 2. INSL-3 immunostaining was increased significantly in group 3 compared to group 2. Our findings indicate that proanthocyanidin ameliorated diabetes related testicular dysfunction. Proanthocyanidin contributes to a balanced oxidant-antioxidant status, and balanced proliferation and apoptosis activity in the germinal cells.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [114S453]en_US
dc.description.sponsorshipOur work was supported by The Scientific and Technological Research Council of Turkey as grant number [114S453].en_US
dc.identifier.doi10.1080/10520295.2021.2002931
dc.identifier.endpage371en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid34789048en_US
dc.identifier.scopus2-s2.0-85119441914en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.2002931
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18243
dc.identifier.volume97en_US
dc.identifier.wosWOS:000720175100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAkten_US
dc.subjectIL-1 Betaen_US
dc.subjectApoptosis INSL-3en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectJNKen_US
dc.subjectProanthocyanidinen_US
dc.subjectRaten_US
dc.subjectTestisen_US
dc.subjectTGF-Beta 1en_US
dc.subjectInsulin-Like Factor-3en_US
dc.subjectOxidative Stressen_US
dc.subjectZinc-Deficiencyen_US
dc.subjectDown-Regulationen_US
dc.subjectActivationen_US
dc.subjectExpressionen_US
dc.subjectToxicityen_US
dc.subjectFormaldehydeen_US
dc.subjectExtracten_US
dc.subjectPathwayen_US
dc.titleRole of JNK, TGF-?1, Akt, IL-1? and INSL-3 in proanthocyanidin protection against apoptosis in diabetic rat testisen_US
dc.typeArticleen_US

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