Development and characterization of oxaceprol-loaded poly-lactide-co-glycolide nanoparticles for the treatment of osteoarthritis

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dc.authoridBal Öztürk, Ayça/0000-0002-6502-528X;
dc.authorwosidKarsli-Ceppioglu, Seher/JED-4667-2023
dc.authorwosidBal Öztürk, Ayça/M-4472-2018
dc.authorwosidDemirbağ, Çağlar/KII-5788-2024
dc.contributor.authorAlarcin, Emine
dc.contributor.authorDemirbag, Caglar
dc.contributor.authorKarsli-Ceppioglu, Seher
dc.contributor.authorKerinnoglu, Oya
dc.contributor.authorBal-Ozturk, Ayca
dc.date.accessioned2024-06-12T11:07:13Z
dc.date.available2024-06-12T11:07:13Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis. In the present study, we aimed to develop and characterize oxaceprol-loaded poly-lactide-co-glycolide (PLGA) nanoparticles for intra-articular administration in osteoarthritis. PLGA nanoparticles were prepared by double-emulsion solvent evaporation method. Meanwhile, a straightforward and generally applicable high performance liquid chromatography method was developed, and validated for the first time for the quantification of oxaceprol. To examine the drug carrying capacity of nanoparticles, varying amount of oxaceprol was entrapped into a constant amount of polymer matrix. Moreover, the efficacy of drug amount on nanoparticle characteristics such as particle size, zeta potential, morphology, drug entrapment, and in vitro drug release was investigated. Nanoparticle sizes were between 229 and 509 nm for different amount of oxaceprol with spherical smooth morphology. Encapsulation efficiency ranged between 39.73 and 63.83% by decreasing oxaceprol amount. The results of Fourier transform infrared and DSC showed absence of interaction between oxaceprol and PLGA. The in vitro drug release from these nanoparticles showed a sustained release of oxaceprol over 30 days. According to cell culture studies, oxaceprol-loaded nanoparticles had no cytotoxicity with high biocompatibility. This study was the first step of developing an intra-articular system in the treatment of osteoarthritis for the controlled release of oxaceprol. Our findings showed that these nanoparticles can be beneficial for an effective treatment of osteoarthritis avoiding side effects associated with oral administration.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Coordination Unit [SAG-A-120613-0234]en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Coordination Unit, Grant/Award Number: SAG-A-120613-0234en_US
dc.identifier.doi10.1002/ddr.21642
dc.identifier.endpage510en_US
dc.identifier.issn0272-4391
dc.identifier.issn1098-2299
dc.identifier.issue4en_US
dc.identifier.pmid31958153en_US
dc.identifier.scopus2-s2.0-85078678014en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage501en_US
dc.identifier.urihttps://doi.org/10.1002/ddr.21642
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21962
dc.identifier.volume81en_US
dc.identifier.wosWOS:000508046800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDrug Development Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntra-Articular Injectionen_US
dc.subjectNanoparticleen_US
dc.subjectOsteoarthritisen_US
dc.subjectOxaceprolen_US
dc.subjectPLGAen_US
dc.subjectIntraarticular Delivery Systemen_US
dc.subjectPlga Nanoparticlesen_US
dc.subjectAtypical Inhibitoren_US
dc.subjectSustained-Releaseen_US
dc.subjectDrug-Deliveryen_US
dc.subjectParticle-Sizeen_US
dc.subjectCellen_US
dc.subjectInflammationen_US
dc.subjectMicroparticlesen_US
dc.subjectDiclofenacen_US
dc.titleDevelopment and characterization of oxaceprol-loaded poly-lactide-co-glycolide nanoparticles for the treatment of osteoarthritisen_US
dc.typeArticleen_US

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