In vivo activity assessment of some Tanacetum species used as traditional wound healer along with identification of the phytochemical profile by a new validated HPLC method

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dc.authoridISCAN, Gülçin SALTAN/0000-0001-6633-0713
dc.authoridAcıkara, Özlem Bahadır/0000-0003-0809-784X
dc.authoridIlhan, Mert/0000-0001-5042-3915
dc.authoridOZBILGIN, Serkan/0000-0002-3945-6756
dc.authoridSUNTAR, IPEK/0000-0003-4201-1325
dc.authorwosidAkkol, Esra/ABI-4678-2020
dc.authorwosidIlhan, Mert/HLH-6199-2023
dc.authorwosidISCAN, Gülçin SALTAN/AAG-8646-2020
dc.authorwosidSüntar, İpek/AHE-1026-2022
dc.authorwosidAcıkara, Özlem Bahadır/AAH-4682-2020
dc.authorwosidKeles, Hikmet/H-4399-2018
dc.contributor.authorOzbilgin, Serkan
dc.contributor.authorAkkol, Esra Kupeli
dc.contributor.authorOz, Burcin Ergene
dc.contributor.authorIlhan, Mert
dc.contributor.authorSaltan, Gulcin
dc.contributor.authorAcikara, Ozlem Bahadir
dc.contributor.authorTekin, Mehmet
dc.date.accessioned2024-06-12T10:52:39Z
dc.date.available2024-06-12T10:52:39Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective(s): Tanacetum species are traditionally used as insecticide, and externally wound healer as well as for anti-inflammatory and antihistaminic properties. The in vivo wound-healing and anti-inflammatory potential of four Tanacetum species, Tanacetum argenteum (Lam.) Willd. subsp. argenteum (TA), Tanacetum heterotomum (Bornm.) Grierson (TH), Tanacetum densum (Lab.) Schultz Bip. subsp. sivasicum (TD), and Tanacetum vulgare L. (TV) was investigated. Materials and Methods: The chloroform (CHCl3) and methanol: water (80: 20) extracts were prepared from the aerial parts of each plant. For assessment of the wound-healing activity, linear incision on rats and circular excision on mice wound models were used and histopathological analyses were conducted on the tissues treated with the test materials. For the evaluation of the anti-inflammatory activity, Whittle Method based on the inhibition of the acetic acid-induced increase in capillary permeability was used. In order to elucidate the phytochemical contents of the extracts, HPLC profiles of active fractions were screened and quantitative analysis was conducted within the scope of HPLC analysis. Results: The CHCl3 extracts of TD, TA and TV were found to have significant wound healing activity (37.1%, 30.8% and 26.1% tensile strength; 88.05%, 72.93% and 44.88% contraction values, respectively) and anti-inflammatory activities (31.5% and 26.6% inhibition values for TD and TA). Parthenolide content of the CHCl3 extracts of TA, TH and TV were found 242.66 +/- 1.53, 190.16 +/- 5.62 and 177.51 +/- 3.73 mu g/100 mg plant material, respectively. Conclusion: According to the results, the other secondary metabolites present in the aerial parts of the Tanacetum species possibly exerted synergistic effects on the observed healing of the wounds.en_US
dc.description.sponsorshipGazi University Ethical Council [G.U.ET-10.027]en_US
dc.description.sponsorshipThroughout the experiments, animals were processed according to the suggested European ethical guidelines for the care of laboratory animals. The present study was performed according to the international rules considering the animal experiments and biodiversity rights (Gazi University Ethical Council Project Number: G.U.ET-10.027).en_US
dc.identifier.doi10.22038/IJBMS.2018.24258.6055
dc.identifier.endpage152en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue2en_US
dc.identifier.pmid29456811en_US
dc.identifier.scopus2-s2.0-85041744834en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2018.24258.6055
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18788
dc.identifier.volume21en_US
dc.identifier.wosWOS:000428717600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsteraceaeen_US
dc.subjectAnti-Inflammatoryen_US
dc.subjectExcisionen_US
dc.subjectIncisionen_US
dc.subjectTanacetumen_US
dc.subjectWound-Healingen_US
dc.subjectAntiinflammatory Activityen_US
dc.subjectEssential Oilsen_US
dc.subjectSesquiterpene Lactonesen_US
dc.subjectProphylactic Treatmenten_US
dc.subjectVar.-Chiliophyllumen_US
dc.subjectMount Hermonen_US
dc.subjectVulgareen_US
dc.subjectPartheniumen_US
dc.subjectFeverfewen_US
dc.subjectExtracten_US
dc.titleIn vivo activity assessment of some Tanacetum species used as traditional wound healer along with identification of the phytochemical profile by a new validated HPLC methoden_US
dc.typeArticleen_US

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