Evaluation of Cardiac Autonomic Dysfunction in Patients With Duchenne-type Muscular Dystrophy

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dc.authorwosidbornaun, helen/HNI-1932-2023
dc.authorwosidnişli, kemal/AAT-6434-2020
dc.authorwosidÖmeroğlu, Rukiye Nurten/AAT-7658-2020
dc.contributor.authorYilmazer, Murat Muhtar
dc.contributor.authorOmeroglu, Rukiye Eker
dc.contributor.authorBornaun, Helen
dc.contributor.authorOner, Naci
dc.contributor.authorNisli, Kemal
dc.date.accessioned2024-06-12T10:59:54Z
dc.date.available2024-06-12T10:59:54Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the presence of cardiac autonomic dysfunction by time-domain heart rate variability analysis in patients with Duchenne Muscular Dystrophy (DMD). Methods: We evaluated cardiac autonomic function by time-domain heart rate variability analysis on 24-hour Holter ECG recordings in 43 patients with DMD and 34 healthy male controls. The variability of the heart rate and its circadian rhythm were assessed. The results of time-domain analyses were compared between study and control group. In addition left ventricular end-diastolic diameter, left ventricular ejection fraction and fractional shortening were measured by 2-dimensional echocardiography. Results: The mean age of study group was 8.79 +/- 3.0 years (range, 3 to 17 years), and control group was 9.52 +/- 3.1 years (range, 4 to 16 years). All of the time-domain parameters (NN, SDNN, SDANN, SDNN-i, RMSSD, pNN50) of the study group were significantly lower than control group. However no significant difference was found in left ventricular end-diastolic diameter on echocardiographic examination between study and control groups. Conclusion: The time-domain parameters were found to be decreased significantly in DMD patients. Our data showed a marked impairment of cardiac autonomic function in patinets with DMD, which reflect to mainly involve the parasympathetic activity. We concluded that autonomic dysfunction has developed in the earlier period in DMD before the development of mechanical cardiac dysfunctionen_US
dc.identifier.endpage19en_US
dc.identifier.issn1302-1664
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77950634542en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage12en_US
dc.identifier.trdizinid122512en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/122512
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20619
dc.identifier.volume27en_US
dc.identifier.wosWOS:000277159000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal Of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDuchenne-Type Muscular Dystrophyen_US
dc.subjectHeart Rate Variabilityen_US
dc.subjectAutonomic Dysfunctionen_US
dc.subjectHeart-Rate-Variabilityen_US
dc.titleEvaluation of Cardiac Autonomic Dysfunction in Patients With Duchenne-type Muscular Dystrophyen_US
dc.typeArticleen_US

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