Prognostic Value of Angiogenesis and Survivin Expression in Patients with Glioblastoma

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dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authorwosidTokuç, Burcu/ABF-7730-2021
dc.authorwosidguler, beril/GYV-3937-2022
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.contributor.authorTastekin, Ebru
dc.contributor.authorCaloglu, Vuslat Yurut
dc.contributor.authorOz Puyan, Fulya
dc.contributor.authorTokuc, Burcu
dc.contributor.authorCaloglu, Murat
dc.contributor.authorYalta, Tulin Deniz
dc.contributor.authorCan, Nuray
dc.date.accessioned2024-06-12T11:02:41Z
dc.date.available2024-06-12T11:02:41Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAIM: Glioblastoma (GBM) is the most common and the most aggressive primary brain tumor with poor prognosis. We aimed to evaluate the association between immunohistochemical expression of survivin and angiogenic parameters (microvessel density and vascular pattern) in patients who underwent surgery for GBM. MATERIAL and METHODS: The pathology reports and also clinical and follow-up data of patients with GBM were retrospectively evaluated. Control tissues were obtained from the archive for each antibody (Survivin, CD 34). Then, control staining of these antibodies was performed. Vessels were evaluated according to the standardized assessment of vascular pattern. RESULTS: Mean survival for classical vascular pattern was longer than bizarre vascular pattern (p<0.001). The survival time of patients decreased with increasing score of survivin staining. There was a significant correlation between survivin and survival time (p<0.001). There was no significant correlation between microvessel density and survival time (p>0.05). CONCLUSION: With these findings, it is considered that high expression of survivin, bizarre vascular pattern and development of secondary GBM correlates with the low survival rates, however microvessel density has no correlation with the survival rates. Since only malignant cells express survivin, it might be a target protein for the development of novel therapies.en_US
dc.identifier.doi10.5137/1019-5149.JTN.16552-15.1
dc.identifier.endpage490en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.pmid27400093en_US
dc.identifier.scopus2-s2.0-85016923430en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage484en_US
dc.identifier.trdizinid262657en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.16552-15.1
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/262657
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21381
dc.identifier.volume26en_US
dc.identifier.wosWOS:000381591600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlioblastomaen_US
dc.subjectSurvivinen_US
dc.subjectVascular Patternen_US
dc.subjectSurvivalen_US
dc.subjectVascular Patternsen_US
dc.subjectGene-Therapyen_US
dc.subjectCanceren_US
dc.subjectApoptosisen_US
dc.subjectTumorsen_US
dc.subjectInhibitoren_US
dc.subjectMultiformeen_US
dc.subjectStrategiesen_US
dc.subjectResistanceen_US
dc.subjectProteinen_US
dc.titlePrognostic Value of Angiogenesis and Survivin Expression in Patients with Glioblastomaen_US
dc.typeArticleen_US

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