Effects of pregabalin on spinal fusion

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dc.authoridimre, erdi/0000-0003-2893-721X
dc.authoridTastekin, Ebru/0000-0002-7686-7765
dc.authoridCiftdemir, Mert/0000-0002-9677-2819
dc.authorwosidimre, erdi/JJD-8213-2023
dc.contributor.authorImre, Erdi
dc.contributor.authorCiftdemir, Mert
dc.contributor.authorTastekin, Ebru
dc.date.accessioned2024-06-12T11:15:30Z
dc.date.available2024-06-12T11:15:30Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose Gamma-aminobutyric acid analogues are commonly used to treat neuropathic and chronic pain before and after spinal surgery in recent years. Aim of this study is to investigate the influence of pregabalin on spinal fusion and to determine the proper pregabalin dose for postoperative utilization in a validated rat intertransverse spinal fusion. Methods Lumbar intertransverse fusion surgeries performed in four groups of rats according to a previously established rat model for posterolateral spinal fusion. All rats were followed up for 6 weeks at the postoperative period by administering oral pregabalin doses of 10 (D10), 30 (D30) and 100 mg/kg/day (D100) except the control group. All rats were killed after 6 weeks and evaluated in terms of manual palpation, radiographic investigation and histological analysis to investigate posterolateral fusion. Results Assessment of fusion with manual palpation revealed lower fusion rates in D100 group. In histological analysis, scores were significantly lower in D30 and D100 groups compared to the control group; this finding was interpreted as inhibition of spinal fusion. Radiographic evaluation did not reveal any significant statistical difference between groups. Conclusions Histological analysis and manual palpation results showed inhibition of spinal fusion formation with high doses of pregabalin. According to these results, administration of high-dose pregabalin should be avoided at the postoperative period until successful fusion is obtained in patients who undergo spinal fusion surgery. Graphic abstract These slides can be retrieved under electronic supplementary material.en_US
dc.identifier.doi10.1007/s00586-019-06226-4
dc.identifier.endpage339en_US
dc.identifier.issn0940-6719
dc.identifier.issn1432-0932
dc.identifier.issue2en_US
dc.identifier.pmid31745644en_US
dc.identifier.scopus2-s2.0-85075390159en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage332en_US
dc.identifier.urihttps://doi.org/10.1007/s00586-019-06226-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23966
dc.identifier.volume29en_US
dc.identifier.wosWOS:000519371700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Spine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpinal Fusionen_US
dc.subjectPregabalinen_US
dc.subjectNeuropathic Painen_US
dc.subjectBone Healingen_US
dc.subjectLow-Back-Painen_US
dc.subjectBone-Graftsen_US
dc.subjectSubstance-Pen_US
dc.subjectRat Modelen_US
dc.subjectGabapentinen_US
dc.subjectActivationen_US
dc.titleEffects of pregabalin on spinal fusionen_US
dc.typeArticleen_US

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