Effects of Hyalobarrier gel and Seprafilm in preventing peritendinous adhesions following crush-type injury in a rat model

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dc.authoridSIKAR, Hasan Ediz/0000-0003-3989-303X
dc.authorwosidSIKAR, Hasan Ediz/R-4695-2019
dc.contributor.authorSikar, Emel Yurdakul
dc.contributor.authorSikar, Hasan Ediz
dc.contributor.authorTop, Husamettin
dc.contributor.authorAygit, Ahmet Cemal
dc.date.accessioned2024-06-12T11:03:24Z
dc.date.available2024-06-12T11:03:24Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: In the present study, the aim was to evaluate the effects of Hyalobarrier gel (Anika Therapeutics S.r.l., Abano Terme, Italy) and Seprafilm adhesion barrier (Genzyme Corporation, Cambridge, MA, USA) in the prevention of peritendinous adhesions following a crush-type injury. METHODS: Twenty five female Wistar Albino rats, weighing 230 to 270 g and 7 to 9 months of age were randomized into 5 groups. Group 1 was the control group, Group 2 comprised the Hyalobarrier gel group, Group 3 was made up of the Seprafilm-treated subjects, Group 4 was the tendon repair and Hyalobarrier gel group, and Group 5 was the tendon repair and Seprafilm group. Two gastrocnemius muscle tendons of each animal, a total of 50 tendons, were used. The animals were sacrificed with the administration of a high dose of anesthetic on postoperative day 40. Macroscopic evaluation of adhesions was classified by 2 blinded researchers according to Tang's adhesion grading system. The number of fibroblasts and the density and formation of collagen fibers were noted for histopathological examination. RESULTS: None of the subjects in Group 2 was determined to have a severe adhesion, and moderate or severe adhesions were detected in Groups 3, 4, and 5. There was no statistically significant difference between Group 2 and the control group (p= 0.737). Groups 3, 4, and 5 demonstrated fewer adhesions than Groups 1 and 2 (p<0.05). Groups 4 and 5 had fewer adhesions than Groups 2 and 3 (p< 0.05). There was no statistically significant difference between Groups 4 and 3 (p= 0.342). The histopathological findings were consistent with the macroscopic findings. CONCLUSION: Seprafilm was found to be effective in the prevention of peritendinous adhesions following a crush-type injury with or without repair of the tendon fibers. In contrast, Hyalobarrier gel was found to be effective only following repair of the tendon fibers.en_US
dc.identifier.doi10.5505/tjtes.2018.54007
dc.identifier.endpage98en_US
dc.identifier.issn1306-696X
dc.identifier.issue2en_US
dc.identifier.pmid30892673en_US
dc.identifier.scopus2-s2.0-85063256137en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage93en_US
dc.identifier.trdizinid341412en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2018.54007
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/341412
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21646
dc.identifier.volume25en_US
dc.identifier.wosWOS:000461479100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyaluronic Aciden_US
dc.subjectSeprafilmen_US
dc.subjectSurgical Adhesionsen_US
dc.subjectTendon Injuriesen_US
dc.subjectAchilles-Tendonen_US
dc.subjectFlexoren_US
dc.subjectRepairen_US
dc.subjectFilmen_US
dc.titleEffects of Hyalobarrier gel and Seprafilm in preventing peritendinous adhesions following crush-type injury in a rat modelen_US
dc.typeArticleen_US

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