Vitamin C protects against ionizing radiation damage to goblet cells of the ileum in rats

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAkpolat, Meryem
dc.date.accessioned2024-06-12T11:04:02Z
dc.date.available2024-06-12T11:04:02Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the present study was to evaluate the radioprotective effect of vitamin C on gamma-radiation-induced damage to goblet cells of the ileum. Thirty mate Wistar albino rats weighing between 250 and 300 g were randomized into the following study groups: I, control; II, single dose radiation treated; III, two dose radiation treated with a 4-day interval between doses; IV, single dose radiation treated with vitamin C; V, two dose radiation treated with vitamin C. Each group contained six animals. The rats in groups Wand V were given a daily dose of 100 mg/kg of vitamin C for 14 and 18 days, respectively. During the vitamin C administration period, the rats in group IV were exposed in the abdominal area to a gamma-ray dose of 5 Gy on day 10 and group V was exposed to same dose of radiation on days 10 and 14. Irradiation and treatment groups were decapitated 4 days after exposure to single or two dose irradiation and ileum tissues were removed for tight and electron microscopic investigation. Single or two dose gamma-irradiation caused a marked intestinal, mucosal injury in rats. Radiation produced increases in the number of goblet cells. Using transmission electron microscopy, extensions in the area between the cells, disorders in the microvilli, mitochondrial damage and endoplasmic reticulum (ER) cisternae dilatation were observed. Antioxidant treatment with vitamin C prior to irradiation provided protection against intestinal damage. (c) 2008 Elsevier GmbH. All rights reserved.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkeyen_US
dc.description.sponsorshipThis study was supported as Project 633 by Trakya University Research Center, Edirne, Turkey. The authors would like to thank Associate Professor Doctor Mustafa Cem Uzal and M.Sc. Fadime Alkaya for irradiation studies.en_US
dc.identifier.doi10.1016/j.acthis.2008.07.006
dc.identifier.endpage490en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue6en_US
dc.identifier.pmid19007656en_US
dc.identifier.scopus2-s2.0-55449126868en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage481en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2008.07.006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21887
dc.identifier.volume110en_US
dc.identifier.wosWOS:000261728200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIrradiationen_US
dc.subjectRadio Protectionen_US
dc.subjectVitamin Cen_US
dc.subjectIleumen_US
dc.subjectGoblet Cellen_US
dc.subjectMorphometryen_US
dc.subjectRaten_US
dc.subjectIrradiated Small-Intestineen_US
dc.subjectMouse Small Intestineen_US
dc.subjectInduced Dna-Damageen_US
dc.subjectBeta-Caroteneen_US
dc.subjectMucosaen_US
dc.subjectRadioprotectionen_US
dc.subjectMucinsen_US
dc.subjectDifferentiationen_US
dc.subjectRadiotherapyen_US
dc.subjectResponsesen_US
dc.titleVitamin C protects against ionizing radiation damage to goblet cells of the ileum in ratsen_US
dc.typeArticleen_US

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