Impact of venous tumour thrombus consistency (solid vs friable) on cancer-specific survival in patients with renal cell carcinoma

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dc.contributor.authorAkdere, Hakan
dc.contributor.authorKuyumcuoglu, Ugur
dc.date.accessioned2024-06-12T11:13:31Z
dc.date.available2024-06-12T11:13:31Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: To our knowledge, the impact of venous tumour thrombus (VTT) consistency in patients affected by renal cell carcinoma (RCC) has never been addressed. To analyse the effect of VTT consistency on cancer-specific survival (CSS). Methods: We retrospectively analysed 174 consecutive patients with RCC and renal vein or vena cava inferior (VCI) VTT who underwent surgical treatment between 1989 and 2007 at our institute. All patients underwent radical nephrectomy and thrombectomy. Pathologic specimens were reviewed by a single uropathologist. In addition to traditional pathologic features, the morphologic aspect of the tumour thrombus was evaluated to distinguish solid from friable patterns. The prognostic role of thrombus consistency (solid vs friable) on CSS was assessed by means of Cox regression models. Results: The VTT was solid in 107 patients (61.5 %) and friable in 67 patients (38.5 %). The presence of a friable VTT increased the risk of having synchronous nodal or distant metastases, higher tumour grade, higher pathologic stage, and simultaneous perinephric fat invasion (all p < 0.05). The median follow-up was 24 mo. The median CSS was 33 mo; the median CSS was 8 mo in patients with a friable VTT and 55 mo in patients with a solid VTT (p<0.001). On multivariable analyses, the presence of a friable VTT was an independent predictor of CSS (p=0.02). The power of our conclusion may be somewhat limited by the relatively small study population and the retrospective nature of the study. Conclusions: In patients with RCC and VTT, the presence of a friable thrombus is an independent predictor of CSS. If our finding is confirmed by further studies, the consistency of the tumour thrombus should be introduced into routine pathologic reports to provide better patient risk stratification.en_US
dc.identifier.endpage259en_US
dc.identifier.issn2147-2270
dc.identifier.issue3en_US
dc.identifier.startpage256en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23586
dc.identifier.volume11en_US
dc.identifier.wosWOS:000219391400018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofUroonkoloji Bulteni-Bulletin Of Urooncologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal Cell Carsinomaen_US
dc.subjectThrombusen_US
dc.subjectCancer-Specific Survivalen_US
dc.titleImpact of venous tumour thrombus consistency (solid vs friable) on cancer-specific survival in patients with renal cell carcinomaen_US
dc.typeEditorialen_US

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