Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model

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dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorBenlier, Erol
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorKandulu, Huseyin
dc.contributor.authorUnal, Yasin
dc.contributor.authorTop, Husamettin
dc.contributor.authorAygit, Ahmet Cemal
dc.date.accessioned2024-06-12T11:00:10Z
dc.date.available2024-06-12T11:00:10Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description6th Congress of the Balkan-Association-of-Plastic-Reconstructive-and-Aesthetic-Surgery -- JUN 04-07, 2009 -- Ohrid, MACEDONIAen_US
dc.description.abstractBackground: Electrical injuries induce progressive tissue loss caused by free oxygen radicals released from neutrophil aggregates. Fucoidin, a potent inhibitor of L-selectin function, reduces the aggregation of neutrophils. The aim of this study was to evaluate the effect of fucoidin on tissue damage in rat electrical burn injury model. Methods: Forty-two male Wistar albino rats (250-300 g) were divided into 3 groups (Group A (n = 6), control group without electrical burn injury; Groups B (n = 18) and C (n = 18), electrical burn injury groups without and with fucoidin therapy, respectively). Three separate analyses were performed at different time points on 6 out of 18 mice from Group B and C at each time point. Biochemistry (myeloperoxidase and malondialdehyde levels) and histopathology (number of neutrophils) of the skin and muscle biopsies at 1st hour; tissue edema (ratio of wet weight/dry weight of extremities) at 24th hour; and necrotic areas at 7th day after electrical injury were evaluated. The electrical burn was induced by exposing rats to 220 V AC between their left upper extremity and right lower extremity for 10 s. Fucoidin was administered as 25 mg/kg intravenous bolus injection at 15 mm after electrical burn injury. Results: Myeloperoxidase and malondialdehyde levels, number of neutrophils, tissue edema, and necrotic area were significantly less in fucoidin-applied rats than the group without fucoidin therapy. Conclusions: Fucoidin inhibits tissue damage induced by electrical burn injury in rats by reducing necrotic area, edema and number of neutrophils. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.en_US
dc.description.sponsorshipBalkan Assoc Plast Reconstruct & Aesthet Surgen_US
dc.identifier.doi10.1016/j.burns.2011.04.008
dc.identifier.endpage1221en_US
dc.identifier.issn0305-4179
dc.identifier.issn1879-1409
dc.identifier.issue7en_US
dc.identifier.pmid21641115en_US
dc.identifier.scopus2-s2.0-80052961047en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1216en_US
dc.identifier.urihttps://doi.org/10.1016/j.burns.2011.04.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20727
dc.identifier.volume37en_US
dc.identifier.wosWOS:000296075600019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBurnsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectric Burnen_US
dc.subjectFucoidinen_US
dc.subjectNeutrophilen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectMalonyldialdehydeen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectThermal-Injuryen_US
dc.subjectPolysaccharide Fucoidinen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectMeningitisen_US
dc.subjectManagementen_US
dc.subjectAdhesionen_US
dc.subjectTraumaen_US
dc.subjectSkinen_US
dc.titleFucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury modelen_US
dc.typeConference Objecten_US

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