Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia

Basit Öğe Kaydı
dc.contributor.authorGurel, Elif Ezgi
dc.contributor.authorUral, Keremcan
dc.contributor.authorOzturk, Gulnur
dc.contributor.authorOzturk, Levent
dc.date.accessioned2024-06-12T11:14:13Z
dc.date.available2024-06-12T11:14:13Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Rapid eye movement (REM) sleep deprivation induces hyperalgesia in healthy rats. Here, we evaluated the effects of flurbiprofen, an anti-inflammatory and neuroprotective agent, on the increased thermal responses observed in REM sleep deprived rats. Methods: Forty female rats were divided into four groups following 96-hour REM sleep deprivation: intraperitoneal injections of placebo, and flurbiprofen 5 mg/kg, 15 mg/kg and 40 mg/kg were made in CONT (n = 10), FBP5, FBP15 and FBP40 groups respectively. Pain threshold measurements were performed three times at baseline (0.hour), at the end of REM sleep deprivation (96.hour) and at 1 h after injections (97.hour) by hot plate and tail-flick tests. Results: REM sleep deprivation induced a significant decrease in pain thresholds of all rats (hotplate: 0.hour vs 96.hour, 9.75 +/- 2.85 vs 5.10 +/- 2.02, p < 0.001; tail flick: 0.hour vs 96.hour, 11.92 +/- 4.62 vs 7.92 +/- 5.15, p < 0.001). Flurbiprofen in 15 mg/kg and 40 mg/kg doses significantly improved pain tolerance measured by tail flick test (tail flick in FBP15 and FBP40 groups: 96.hour vs 97.hour, 7.01 +/- 4.97 vs 8.34 +/- 3.61 and 5.06 +/- 1.57 vs 7.04 +/- 2.49, p < 0.05 for both). Conclusion: 96 h of REM sleep deprivation resulted in reduced pain thresholds in both hot plate and tail flick tests. Flurbiprofen was used for the first time in a rat model of REM sleep deprivation, and it provided antinociceptive effects in 15 mg/kg and 40 mg/kg doses. Flurbiprofen may have the potential for treatment of painful syndromes accompanying insomnia or sleep loss. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects [TUBAP-2012/26]en_US
dc.description.sponsorshipThis study was supported by a grant of Trakya University Scientific Research Projects (Project number TUBAP-2012/26). We are grateful to Assoc. Prof. Dr. Necdet Sut for conducting all statistical analyses. None of the authors are related with any drug company and have conflict of interesten_US
dc.identifier.doi10.1016/j.physbeh.2014.02.003
dc.identifier.endpage158en_US
dc.identifier.issn0031-9384
dc.identifier.pmid24534174en_US
dc.identifier.scopus2-s2.0-84894417523en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1016/j.physbeh.2014.02.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23856
dc.identifier.volume128en_US
dc.identifier.wosWOS:000335106200023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPhysiology & Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSleep Lossen_US
dc.subjectFlurbiprofenen_US
dc.subjectAnti-Nociceptiveen_US
dc.subjectPain Thresholden_US
dc.subjectREM Deprivationen_US
dc.subjectFocal Cerebral-Ischemiaen_US
dc.subjectEnkephalinase-Inhibitionen_US
dc.subjectPain Thresholdsen_US
dc.subjectRemen_US
dc.subjectRaten_US
dc.subjectReceptorsen_US
dc.subjectRecoveryen_US
dc.subjectActivationen_US
dc.subjectDrugsen_US
dc.titleFlurbiprofen in rapid eye movement sleep deprivation induced hyperalgesiaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu