Dental Fluorosis and Catalase Immunoreactivity of the Brain Tissues in Rats Exposed to High Fluoride Pre- and Postnatally

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dc.authoridBOZKURT, SUHEYLA UYAR uyar/0000-0002-5947-947X
dc.authoridBOZKURT, SÜHEYLA UYAR/0000-0002-5947-947X
dc.authoridmentes, ali/0000-0002-2778-6803
dc.authoridOnur, Şirin Güner/0000-0002-6890-3500
dc.authoridHAZNEDAROGLU, Eda/0000-0003-0792-2465
dc.authorwosidBOZKURT, SUHEYLA UYAR uyar/A-8912-2016
dc.authorwosidBOZKURT, SÜHEYLA UYAR/JVO-9637-2024
dc.authorwosidmentes, ali/HJZ-1125-2023
dc.authorwosidHaznedaroğlu, Eda/AAA-9039-2019
dc.authorwosidHaznedaroğlu, Eda/U-6139-2019
dc.authorwosidOnur, Şirin Güner/AAL-3712-2021
dc.contributor.authorGuner, Sirin
dc.contributor.authorUyar-Bozkurt, Suheyla
dc.contributor.authorHaznedaroglu, Eda
dc.contributor.authorMentes, Ali
dc.date.accessioned2024-06-12T11:02:03Z
dc.date.available2024-06-12T11:02:03Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study evaluated dental fluorosis of the incisors and immunoreactivity in the brain tissues of rats given chronic fluoride doses pre- and postnatally. Female rats were given drinking water with 0, 30 or 100 ppm fluoride ad libitum throughout gestation and the nursing period. In addition, 63 male offspring were treated with the same water regimens as the mothers after weaning and were followed for 1, 3 or 5 months. The upper and lower incisors were collected, and all teeth were examined under a stereomicroscope and scored by two blinded examiners using a modified rodent enamel fluorosis index. Cortical, hippocampal and cerebellar brain samples were evaluated morphologically and immunohistochemically. All fluoride-treated pups were born with low body weight (p = 0.001). All animals from the fluoride groups had enamel fluorosis with defects of various degrees. The increase in the dental fluorosis scores in the fluoride treatment groups was significant (p < 0.01). The catalase immunoreactivity in the 30- and 100-ppm fluoride groups was significantly higher than that in the controls after 1, 3 and 5 months (p < 0.001). In conclusion, this study showed that rats with dental fluorosis had catalase immunoreactivity in the brain tissues, which may reflect the neurobehavioral toxicity of fluoride.en_US
dc.description.sponsorship[SAG-C-DRP-031,210-0275]en_US
dc.description.sponsorshipThis study was funded by SAG-C-DRP-031,210-0275.en_US
dc.identifier.doi10.1007/s12011-016-0695-2
dc.identifier.endpage157en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid27052310en_US
dc.identifier.scopus2-s2.0-84962779252en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage150en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-016-0695-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21129
dc.identifier.volume174en_US
dc.identifier.wosWOS:000385132300019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluoride Toxicityen_US
dc.subjectDental Fluorosisen_US
dc.subjectBrainen_US
dc.subjectCatalaseen_US
dc.subjectRatsen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectOxidative Stressen_US
dc.subjectSodium-Fluorideen_US
dc.subjectInfant Formulaen_US
dc.subjectApoptosisen_US
dc.subjectMiceen_US
dc.subjectNeurotoxicityen_US
dc.subjectAmeliorationen_US
dc.subjectAssociationen_US
dc.subjectCalciumen_US
dc.titleDental Fluorosis and Catalase Immunoreactivity of the Brain Tissues in Rats Exposed to High Fluoride Pre- and Postnatallyen_US
dc.typeArticleen_US

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