Prolonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failure

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridPATHAN, JAVED YASIN/0000-0002-5867-2833
dc.authoridYUVARAJU, PRIYADHARSHINI/0000-0003-2383-457X
dc.authoridNemmar, Abderrahim/0000-0002-0699-1015
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidPATHAN, JAVED YASIN/GOE-4396-2022
dc.contributor.authorNemmar, Abderrahinn
dc.contributor.authorKaraca, Turan
dc.contributor.authorBeegam, Sumaya
dc.contributor.authorYuvaraju, Priya
dc.contributor.authorYasin, Javed
dc.contributor.authorHamadi, Naserddine Kamel
dc.contributor.authorAli, Badreldin H.
dc.date.accessioned2024-06-12T10:51:04Z
dc.date.available2024-06-12T10:51:04Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/Aims: Epidemiological evidence indicates that patients with chronic kidney diseases have increased susceptibility to adverse outcomes related to long-term exposure to particulate air pollution. However, mechanisms underlying these effects are not fully understood. Methods: Presently, we assessed the effect of prolonged exposure to diesel exhaust particles (DEP) on chronic renal failure induced by adenine (0.25% w/w in feed for 4 weeks), which is known to involve inflammation and oxidative stress. DEP (0.5m/kg) was intratracheally (i.t.) instilled every 4th day for 4 weeks (7 i.t. instillation). Four days following the last exposure to either DEP or saline (control), various renal endpoints were measured. Results: While body weight was decreased, kidney weight increased in DEP+adenine versus saline+adenine or DEP. Water intake, urine volume, relative kidney weight were significantly increased in adenine+DEP versus DEP and adenine+saline versus saline. Plasma creatinine and urea increased and creatinine clearance decreased in adenine+DEP versus DEP and adenine+saline versus saline. Tumor necrosis factor alpha, lipid peroxidation and reactive oxygen species were significantly increased in adenine+DEP compared with either DEP or adenine+saline. The antioxidant calase was significantly decreased in adenine+DEP compared with either adenine+saline or DEP Notably, renal DNA damage was significantly potentiated in adenine+DEP compared with either adenine+saline or DEP Similarly, systolic blood pressure was increased in adenine+DEP versus adenine+saline or DEP, and in DEP versus saline. Histological evaluation revealed more collagen deposition, higher number of necrotic cell counts and dilated tubules, cast formation and collapsing glomeruli in adenine+DEP versus adenine+saline or DEP. Conclusion: Prolonged pulmonary exposure to diesel exhaust particles worsen renal oxidative stress, inflammation and DNA damage in mice with adenine-induced chronic renal failure. Our data provide biological plausibility that air pollution aggravates chronic renal failure. (C) 2016 The Author(s) Published by S. Karger AG, Baselen_US
dc.description.sponsorshipUAEU-SQU; College of Medicine and Health Sciences, United Arab Emirates Universityen_US
dc.description.sponsorshipThis work was supported by a UAEU-SQU joint grant provided to both Prof. A. Nemmar (UAEU) and Prof. B.H. Ali (SQU), and by a research grant of the College of Medicine and Health Sciences, United Arab Emirates University.en_US
dc.identifier.doi10.1159/000443109
dc.identifier.endpage1713en_US
dc.identifier.issn1015-8987
dc.identifier.issn1421-9778
dc.identifier.issue5en_US
dc.identifier.pmid27160713en_US
dc.identifier.scopus2-s2.0-84966270248en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1703en_US
dc.identifier.urihttps://doi.org/10.1159/000443109
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18225
dc.identifier.volume38en_US
dc.identifier.wosWOS:000375787800004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofCellular Physiology And Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAir Pollutionen_US
dc.subjectDiesel Exhaust Particlesen_US
dc.subjectAdenineen_US
dc.subjectChronic Kidney Failureen_US
dc.subjectMiceen_US
dc.subjectDNA Damageen_US
dc.subjectOxidative Stressen_US
dc.subjectCisplatin-Induced Nephrotoxicityen_US
dc.subjectParticulate Matteren_US
dc.subjectAccelerates Coagulationen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectChronic Kidneyen_US
dc.subjectAir-Pollutionen_US
dc.subjectGum Acaciaen_US
dc.subjectRatsen_US
dc.subjectToxicityen_US
dc.subjectNoseen_US
dc.titleProlonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failureen_US
dc.typeArticleen_US

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