The effect of combined systemic administration of morphine and L-name, a nitric oxide synthase inhibitor, on behavioral signs of neuropathic pain in rats

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorUlugol, A
dc.contributor.authorAslantas, A
dc.contributor.authorKaradag, HC
dc.contributor.authorBulbul, ED
dc.contributor.authorTuncer, A
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T11:09:10Z
dc.date.available2024-06-12T11:09:10Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe controversy over using opioids for managing chronic neuropathic pain is widely acknowledged, and nitric oxide (NO) is suggested to play an important role in the maintenance of the behavioral signs of neuropathic pain. We evaluated the effect of combined systemic administration of morphine and N-G-nitro-L-arginine-methyl ester (L-NAME), a NO synthase (NOS) inhibitor, on allodynia in the spinal nerve ligation model of pain in rats. Nerve injury was produced by tight ligation of the left L5 and L6 spinal nerves and this procedure resulted in neuropathic pain behaviors in the ipsilateral hindlimb. Mechanical and cold allodynia were detected, respectively, by application of von Frey filaments or acetone to the plantar surface of the foot. Morphine (0.1-10 mg/kg, i.p.) and L-NAME (3-30 mg/kg, i.p.) reduced mechanical and cold allodynia with their higher doses. Combining subthreshold dose of L-NAME (3 mg/kg, i.p.) with morphine, an appreciable increase in the antiallodynic effect of morphine was observed. This effect was prevented by L-arginine (500 mg/kg, i.p.) and naloxone (I mg/kg, i.p.). These results suggest that combining morphine with a NOS inhibitor may be a promising approach in the treatment of neuropathic pain.en_US
dc.identifier.doi10.1002/nrc.10026
dc.identifier.endpage153en_US
dc.identifier.issn0893-6609
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0036071833en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1002/nrc.10026
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22695
dc.identifier.volume30en_US
dc.identifier.wosWOS:000176622100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofNeuroscience Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathic Painen_US
dc.subjectAllodynia Morphineen_US
dc.subjectL-NAMEen_US
dc.subjectNitric Oxideen_US
dc.subjectNmda-Receptor Antagonistsen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectDiabetic Ratsen_US
dc.subjectNociceptive Neuronsen_US
dc.subjectTactile Allodyniaen_US
dc.subjectSpinal-Corden_US
dc.subjectModelen_US
dc.subjectHyperalgesiaen_US
dc.subjectOpioidsen_US
dc.titleThe effect of combined systemic administration of morphine and L-name, a nitric oxide synthase inhibitor, on behavioral signs of neuropathic pain in ratsen_US
dc.typeArticleen_US

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