Increased ascites natural killer cells in patients with chronic hepatitis B cirrhosis using lamivudine: A pilot study
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background and Aims: Natural killer cells play a direct role in liver injury and fibrogenic response. Peripheral blood natural killer cells have been studied widely in chronic liver diseases. We aimed to evaluate the ascites natural killer cell frequency and its significance in chronic hepa-titis B related cirrhosis. Materials and Methods: Overall, 30 patients (23 males) with decompensated chronic hepatitis B cirrhosis with ascites were included. Patients with a recent ascites infection history and other etiologic factors besides chronic hepatitis B infection were excluded. Af-ter defining the demographic characteristics of the cases, we divided patients according to their Child-Turcotte-Pugh classification scores into two groups, and their natural killer (CD3?/CD16+/CD56+) cell frequen-cies in peripheral blood and ascites were studied using flow cytometry. Finally, we compared the natural killer cell frequencies in peripheral blo-od and ascites between the Child-Turcotte-Pugh classification groups ba-sed on lamivudine use. Results: Median lamivudine usage duration was 60 months, interquartile range 18.7–93 months in Child-Turcotte-Pugh B and 7.5 months, interquartile range 2.2–21 months in Child-Turcot-te-Pugh C (p = 0.053). Ascites natural killer cells were significantly incre-ased in lamivudine users of Child-Turcotte-Pugh B (p = 0.049), whereas no change was observed in peripheral blood - natural killer frequency in patients using lamivudine in the Child-Turcotte-Pugh B and C groups (p=0.574 and p = 0.174, respectively). Conclusion: Long-term lamivudine use might have increased the ascites natural killer frequency, whereas no change was observed in the peripheral blood - natural killer cell frequ-ency in patients with chronic hepatitis B cirrhosis, suggesting a potential role of antivirals in ascites natural killer cell response.
Açıklama
Anahtar Kelimeler
Kaynak
Akademik Gastroenteroloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
3
