Bone-Directed Therapy and Breast Cancer: Bisphosphonates, Monoclonal Antibodies, and Radionuclides
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Science+Business Media
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Breast cancer bone metastasis causes severe morbidity and is commonly encountered in daily clinical practice. It causes pain, pathologic fractures, spinal cord, and other nerve compression syndromes and life-threatening hypercalcemia. Breast cancer metastasizes to the bone through a complicated process that involves numerous molecules. Metastatic cells disrupt normal bone turnover and create a vicious cycle. All treatment effort is directed to breaking this vicious cycle. Bisphosphonates have been used safely for more than two decades. As a group, bisphosphonates delay the time to the first skeletal-related event and reduce pain. However, they do not prevent the development of bone metastasis in patients with no bone metastasis and do not prolong survival. The receptor activator for nuclear factor ?B ligand inhibitor denosumab also delays the time to the first skeletal-related event and reduces the skeletal morbidity rate. Radionuclides are another treatment option for bone pain. © Springer Nature Switzerland AG 2019.
Açıklama
Anahtar Kelimeler
A?ß3 Integrin; Bisphosphonate; Cadherin-11; Cathepsin K; Clodronate; Conjunctivitis; Denosumab; E-Selectin; Episcleritis; Farnesyl Pyrophosphate Synthase Enzyme; Hypocalcemia; Ibandronate; Insulin-Like Growth Factor 1 (Igf1); Interleukin 11 (Il-11); Interleukin 6 (Il-6); Intracellular Adhesion Molecule (Icam-1); Iritis; Macrophage Colony-Stimulating Factor (M-Csf); Mevalonate Pathway; Nephrotoxicity; Odanacatib; Osteonecrosis Of The Jaw (Onj); P-Selectin; Pamidronate; Parathyroid Hormone-Related Peptide (Pthrp); Phosphorus-32 (P-32); Prenylation; Prostaglandin E2 (Pge2); Radionuclide; Rhenium-186 Hydroxyethylidene Diphosphonate (Re-186); Samarium-153 Lexidronam (Sm-153); Saracatinib; Scleritis; Src. Dasatinib; Strontium-89 Hydrochloride (Sr-89); Uveitis; Vascular Cell Adhesion Molecule (Vcam-1); Zoledronic Acid
Kaynak
Breast Disease: Management and Therapies: Volume 2, Second Edition
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
2
