Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:16:20Z
dc.date.available2024-06-12T11:16:20Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was designed to investigate the possible beneficial effects of the thymoquinone (TQ) in streptozotocine (STZ)-induced diabetes in rats. The rats were randomly allotted into one of three experimental groups: A (control), B (diabetic untreated), and C (diabetic treated with TQ); each group contain ten animals. B and C groups received STZ. Diabetes was induced in two groups by a single intra-peritoneal (i.p) injection of STZ (50 mg/kg, freshly dissolved in 5 mmol/l citrate buffer, pH 4.5). Two days after STZ treatment, development of diabetes in two experimental groups was confirmed by measuring blood glucose levels in a tail vein blood samples. Rats with blood glucose levels of 250 mg/dl or higher were considered to be diabetic. The rats in TQ treated groups were given TQ (50 mg/kg body weight) once a day orally by using intra gastric intubation for 12 weeks starting 2 days after STZ injection. Treatment of TQ reduced the glomerular size, thickening of capsular, glomerular and tubular basement membranes, increased amounts of mesangial matrix and tubular dilatation and renal function as compared with diabetics untreated. We conclude that TQ therapy causes renal morphologic and functional improvement after STZ-induced diabetes in rats. We believe that further preclinical research into the utility of TQ treatment may indicate its usefulness as a potential treatment in diabetic nephropathy.en_US
dc.identifier.doi10.1007/s10735-009-9220-7
dc.identifier.endpage115en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue2en_US
dc.identifier.pmid19484499en_US
dc.identifier.scopus2-s2.0-67651202351en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-009-9220-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24286
dc.identifier.volume40en_US
dc.identifier.wosWOS:000267784900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectInosen_US
dc.subjectUltrastructureen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectRaten_US
dc.subjectGlomerular-Basement-Membraneen_US
dc.subjectHeparan-Sulfate Proteoglycanen_US
dc.subjectNigella-Sativa Oilen_US
dc.subjectGrowth-Factor-Betaen_US
dc.subjectCollagen Type-Iven_US
dc.subjectHyperlipidemic Nephropathyen_US
dc.subjectAdriamycin Nephropathyen_US
dc.subjectExtracellular-Matrixen_US
dc.subjectOxidative Stressen_US
dc.subjectAngiotensin-Iien_US
dc.titleProtective effects of thymoquinone on streptozotocin-induced diabetic nephropathyen_US
dc.typeArticleen_US

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