The relationship among plasma copeptin, carboxyhemoglobin, and lactate levels in carbon monoxide poisoning

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dc.authoridBülbül, Emre/0000-0003-2574-376X
dc.authoridkavalcı, cemil/0000-0003-2529-2946
dc.authoridOzkan, Seda/0000-0003-1835-8820
dc.authoridSALT, OMER/0000-0002-5557-6627
dc.authorwosidBülbül, Emre/AAD-8199-2021
dc.authorwosidkavalcı, cemil/AGG-1308-2022
dc.authorwosidOzkan, Seda/AAE-8598-2019
dc.authorwosidşen, ahmet/S-1096-2017
dc.contributor.authorOzkan, S.
dc.contributor.authorSalt, O.
dc.contributor.authorDurukan, P.
dc.contributor.authorSen, A.
dc.contributor.authorBulbul, E.
dc.contributor.authorDuman, A.
dc.contributor.authorKavalci, C.
dc.date.accessioned2024-06-12T10:58:29Z
dc.date.available2024-06-12T10:58:29Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of our study is to determine whether there is a change in the plasma levels of copeptin and there is a relationship among the plasma levels of carboxyhemoglobin (COHb), lactate, and copeptin levels in patients presenting to the emergency department with carbon monoxide (CO) poisoning. Methods: Fifty-seven patients admitted to the emergency department with CO poisoning were included in the study. The blood samples of the patients were collected on arrival 0th, 6th, and 12th hours for copeptin, lactate, and COHb levels. Data were analyzed using SPSS-17 statistical software. Results: Arrival serum copeptin levels of the patients were compared to copeptin levels of healthy individuals and a statistically significant difference was found between them (p = 0.008). There was a statistically significant difference between the arrival levels of copeptin and 6th-hour (p = 0.006) and 12th-hour (p = 0.001) levels of copeptin. There was no significant difference between 6th-hour and 12th-hour copeptin levels (p = 0.51). In terms of serum lactate levels, there was a significant difference between arrival and 6th h (p < 0.001), arrival and 12th h (p < 0.001), and 6th and 12th h (p < 0.001). Likewise, in terms of serum COHb levels, there was a significant difference between arrival and 6th h (p < 0.001), arrival and 12th h (p < 0.001), and 6th and 12th h (p < 0.001). There was a positive correlation between COHb and lactate levels on arrival (r = 0.52; p = 0.001). Conclusion: Copeptin as a stress hormone can be used in the diagnosis and monitoring of patients with CO poisoning. However, the copeptin level was not superior to COHb and lactate levels.en_US
dc.identifier.doi10.1177/0960327119886063
dc.identifier.endpage318en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue3en_US
dc.identifier.pmid31680554en_US
dc.identifier.scopus2-s2.0-85074710159en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.1177/0960327119886063
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20087
dc.identifier.volume39en_US
dc.identifier.wosWOS:000495312300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopeptinen_US
dc.subjectCarbon Monoxide Poisoningen_US
dc.subjectLactateen_US
dc.subjectCarboxyhemoglobinen_US
dc.subjectBiomarkersen_US
dc.subjectIntoxicationen_US
dc.subjectSeverityen_US
dc.subjectBlooden_US
dc.titleThe relationship among plasma copeptin, carboxyhemoglobin, and lactate levels in carbon monoxide poisoningen_US
dc.typeArticleen_US

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