Effect of verapamil sustained-release on the sympathetic nervous system response to isometric stress in patients with essential hypertension: A pilot study in Turkish patients

Basit Öğe Kaydı
dc.contributor.authorBicik, Z
dc.contributor.authorAkcan, Y
dc.contributor.authorUgur, B
dc.date.accessioned2024-06-12T11:01:30Z
dc.date.available2024-06-12T11:01:30Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Stress and sympathetic nervous system activation play a major role in the pathogenesis of essential hypertension. Recent data suggest that the calcium channel blocker verapamil, in addition to its antihypertensive effects, can alter the level of norepinephrine released during stress. Objective: The purpose of this study was to examine the effects of verapamil sustained-release (SR) on the sympathetic nervous system response to stress in patients with essential hypertension. Methods: Patients with essential hypertension (diastolic blood pressure >90 mm Hg and systolic blood pressure >140 mm Hg) whose blood pressure was inadequately controlled or uncontrolled were enrolled in the study. Secondary hypertension was ruled out by routine biochemical, endocrine, and radiologic tests. After a 15-day washout period during which all previous antihypertensive medication was discontinued, blood pressure, heart rate, and serum norepinephrine levels were measured at rest and in response to stress (ie, isometric exercise). Patients began treatment with verapamil SR at dosages recommended in the Sixth Report of the Joint National Committee for the Prevention, Diagnosis, Evaluation, and Treatment of High Blood Pressure (240 mg/d for stage I hypertension and 480 mg/d for stage II and stage III hypertension). After 4 weeks of treatment, blood pressure, heart rate, and norepinephrine levels were measured again at rest and in response to stress. Results: Thirteen patients (9 women and 4 men) were enrolled; 9 patients completed the study. Three patients were lost to follow-up and 1 was noncompliant. Verapamil SR significantly lowered norepinephrine levels both at rest and in response to stress (P<0.01), and reduced the increase in norepinephrine levels after isometric exercise. Conclusion: These results suggest that in this small sample of Turkish patients, verapamil SR significantly diminished the sympathetic nervous system response to stress by decreasing norepinephrine levels. This property may make verapamil SR especially useful when there is a need for decreased sympathetic activity (and thereby, a reduction in oxygen consumption) as well as other antihypertensive effects, such as in patients with coronary heart disease.en_US
dc.identifier.doi10.1016/S0011-393X(01)80066-7
dc.identifier.endpage601en_US
dc.identifier.issn0011-393X
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-0034828429en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage595en_US
dc.identifier.urihttps://doi.org/10.1016/S0011-393X(01)80066-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20909
dc.identifier.volume62en_US
dc.identifier.wosWOS:000171094400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical And Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEssential Hypertensionen_US
dc.subjectVerapamilen_US
dc.subjectExerciseen_US
dc.subjectSympathetic Nervous Systemen_US
dc.subjectNorepinephrineen_US
dc.subjectStressen_US
dc.subjectHeart-Rateen_US
dc.subjectExerciseen_US
dc.titleEffect of verapamil sustained-release on the sympathetic nervous system response to isometric stress in patients with essential hypertension: A pilot study in Turkish patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu