Intraarticular analgesia after arthroscopic knee surgery: comparison of neostigmine, clonidine, tenoxicam, morphine and bupivacaine

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dc.authorwosidteng, yj/C-4440-2011
dc.contributor.authorAlagol, A
dc.contributor.authorCalpur, OU
dc.contributor.authorUsar, PS
dc.contributor.authorTuran, N
dc.contributor.authorPamukcu, Z
dc.date.accessioned2024-06-12T10:52:33Z
dc.date.available2024-06-12T10:52:33Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description4th Congress of the European-Federation-of-the-International-Association-for-the-Study-of-Pain-Chapters -- SEP 02-06, 2003 -- Prague, CZECH REPUBLICen_US
dc.description.abstractWe conducted a randomized, placebo-controlled, double blinded study to compare the analgesic effects of intraarticular neostigmine, morphine, tenoxicam, clonidine and bupivacaine in 150 patients undergoing arthroscopic knee surgery. General anaesthesia protocol was same in all patients. At the end of the surgical procedure, patients were randomized into six intraarticular groups equally. Group N received 500 mu g neostigmine, Group M received 2 mg morphine, Group T received 20 mg tenoxicam, Group C received 1 mu g kg(-1) clonidine, Group B received 100 mg bupivacaine and Group S received saline 20 ml. Visual analog scale scores 0, 30 and 60 min and 2, 4, 6, 12, 24, 48 and 72 h, time to first analgesic need, analgesic consumption at 48 h and 72 h and side effects were noted. Demographic and operational parameters were similar in six groups. All study groups provided analgesia when compared with saline group (P<0.05). Duration of analgesia in Group N and C was longer than other groups (P<0.001). Analgesic consumptions of Group N, C and T were lower than other groups (P<0.01). Pain scores during 2 h postoperatively were lower in all study groups than the control group (P<0.001). In Group B, median pain scores were higher than Groups N and C at 0 min and 30 min postoperatively (P<0.001). Side effects were not significantly different among the six groups. We conclude that the most effective drugs that are administered intraarticularly are neostigmine and clonidine among the five drugs we studied. Tenoxicam provided longer analgesia when compared with morphine and bupivacaine, postoperatively.en_US
dc.description.sponsorshipEuropean Federat Int Assoc Study Pain Chaptersen_US
dc.identifier.doi10.1007/s00167-004-0612-7
dc.identifier.endpage663en_US
dc.identifier.issn0942-2056
dc.identifier.issn1433-7347
dc.identifier.issue8en_US
dc.identifier.pmid15912413en_US
dc.identifier.scopus2-s2.0-27744608588en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage658en_US
dc.identifier.urihttps://doi.org/10.1007/s00167-004-0612-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18753
dc.identifier.volume13en_US
dc.identifier.wosWOS:000233236400009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofKnee Surgery Sports Traumatology Arthroscopyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArthroscopic Knee Surgeryen_US
dc.subjectIntraarticular Analgesiaen_US
dc.subjectNeostigmineen_US
dc.subjectClonidineen_US
dc.subjectTenoxicamen_US
dc.subjectMorphineen_US
dc.subjectBupivacaineen_US
dc.subjectPostoperative Analgesiaen_US
dc.subjectCombinationen_US
dc.subjectPainen_US
dc.subjectAnesthesiaen_US
dc.subjectEfficacyen_US
dc.titleIntraarticular analgesia after arthroscopic knee surgery: comparison of neostigmine, clonidine, tenoxicam, morphine and bupivacaineen_US
dc.typeConference Objecten_US

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