Effect of melatonin on cerebral edema in rats

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dc.authoridHAYRAN, HATiCE Mürvet/0000-0001-6058-6304
dc.authoridTuncer, Meltem/0000-0003-0341-7277
dc.authorwosidTuncer, Meltem/IWV-1405-2023
dc.authorwosidGörgülü, Ahmet Orhan/W-1964-2018
dc.authorwosidHAYRAN, HATiCE Mürvet/I-8346-2013
dc.authorwosidTuncer, Meltem/E-9982-2013
dc.contributor.authorGörgülü, AK
dc.contributor.authorPalaoglu, S
dc.contributor.authorIsmailoglu, Ö
dc.contributor.authorTuncel, M
dc.contributor.authorSürücü, MT
dc.contributor.authorErbil, M
dc.contributor.authorKilinç, K
dc.date.accessioned2024-06-12T10:58:04Z
dc.date.available2024-06-12T10:58:04Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: Melatonin (5-methoxy-N-acetyltrypamine), a chemical naturally produced in the pineal gland, has been suggested to be a free radical scavenger and an antioxidant. In the present study, the effect of melatonin on cold-induced brain edema was evaluated by determination of cerebral water content, blood-brain barrier permeability, and areas of infarct; the effects were also studied histopathologically. METHODS: Brain edema was produced in rats by creating a lesion via cortical freezing. Animals were separated into four groups: sham-operated (craniectomy only); control (cold injury); sham-vehicle (cold injury plus saline); and melatonin treatment (cold injury plus melatonin). Melatonin was administered (50 mg/kg intraperitoneally) 15 minutes after the cold injury was induced. Twenty-four hours later, tissue samples from the core, from the periphery of the cold-injured hemisphere, and from the contralateral hemisphere symmetrical to the cold injury were obtained. RESULTS: Melatonin treatment reduced edema (mean +/- standard deviation; 86.22 +/- 1.54% in the control group versus 80.78 +/- 2.76% in the melatonin treatment group, P < 0.001) and blood-brain barrier permeability (45.34 +/- 2.75% in the control group versus 38.26 +/- 3.40% in the melatonin treatment group, P < 0.001) at the periphery of cold injury. Area of infarct reduced from 5.84 +/- 0.58% in the control group to 3.30 +/- 0.89% in the melatonin treatment group (P < 0.001). The effect of melatonin was also confirmed histopathologically. CONCLUSION: Melatonin was found to be neuroprotective in instances of cold-induced brain edema. Thus, melatonin may be a valuable therapeutic agent in the treatment of cerebral edema.en_US
dc.identifier.endpage1441en_US
dc.identifier.issn0148-396X
dc.identifier.issn1524-4040
dc.identifier.issue6en_US
dc.identifier.pmid11846944en_US
dc.identifier.scopus2-s2.0-0035722207en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1434en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19923
dc.identifier.volume49en_US
dc.identifier.wosWOS:000172474500036en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofNeurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCold Injuryen_US
dc.subjectEdemaen_US
dc.subjectMelatoninen_US
dc.subjectTraumatic Brain-Injuryen_US
dc.subjectOxygen-Free-Radicalsen_US
dc.subjectNitric-Oxideen_US
dc.subjectNeurohormone Melatoninen_US
dc.subjectScavenging Activityen_US
dc.subjectAntioxidanten_US
dc.subjectSuperoxideen_US
dc.subjectDamageen_US
dc.subjectCellen_US
dc.subjectPeroxynitriteen_US
dc.titleEffect of melatonin on cerebral edema in ratsen_US
dc.typeArticleen_US

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