Protective effect of L-carnitine versus amifostine against cisplatin-induced nephrotoxicity in rats

Basit Öğe Kaydı
dc.authoridTanriverdi, Ozgur/0000-0002-0598-7284
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridDepboylu Denizli, Bengu/0000-0002-9777-2917
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidTanriverdi, Ozgur/M-2172-2015
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidDepboylu Denizli, Bengu/B-9156-2019
dc.contributor.authorUzunoglu, Sernaz
dc.contributor.authorKaragol, Hakan
dc.contributor.authorOzpuyan, Fulya
dc.contributor.authorCosar, Rusen
dc.contributor.authorCicin, Irfan
dc.contributor.authorYurutcaloglu, Vuslat
dc.contributor.authorDenizli, Bengu
dc.date.accessioned2024-06-12T10:51:23Z
dc.date.available2024-06-12T10:51:23Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe aimed to compare the protective effect of L-carnitine (CAR) and amifostine (AMF) against cisplatin (CDDP)-induced nephrotoxicity through biochemical markers and histopathological evaluation. Fifty-seven Wistar albino male rats were randomly classified into six groups, which were AMF+CDDP (n = 11; 200 mg/kg AMF 30 min prior to 7 mg/kg CDDP), CAR? CDDP (n = 11; 300 mg/kg CAR 30 min prior to 7 mg/kg CDDP), CDDP (n = 11; 1 mL/kg isotonic saline 30 min prior to 7 mg/kg CDDP), AMF (n = 8; 200 mg/kg AMF alone), CAR (n = 8; 300 mg/kg CAR alone), and control (n = 8; 1 mL/kg isotonic saline alone). All drugs were given intra-peritoneally. Five days after medication, animals were killed, and samples of blood and kidney tissues were collected for biochemical and histopathological evaluation. The serum urea level was highest in AMF+CDDP group among CDDP-applied groups without statistical significance (median, range: 88, 56-21 mg/dL; P > 0.05). There was no statistical significance among CDDP-applied groups in terms of creatinine level (P > 0.05). In the AMF+CDDP group, the median glomerular, tubular, and tubulointerstitial inflammatory damage scores were significantly higher than the other CDDP-applied groups (P < 0.001). The difference between CAR? CDDP and CDDP groups was not statistically significant in terms of renal damage scores. AMF? CDDP group had significantly higher median total nephrotoxicity score than all the other groups (P < 0.001). To conclude, AMF or CAR has no protective effect on CDDP-induced nephrotoxicity. Furthermore, our findings suggest that application of AMF before CDDP may enhance CDDP-induced nephrotoxicity histopathologically.en_US
dc.description.sponsorshipTrakya University Scientific Research Center [5266-13951]en_US
dc.description.sponsorshipThis study was supported by Trakya University Scientific Research Center (Ref No: 5266-13951; Sep 9, 2008).en_US
dc.identifier.doi10.1007/s12032-010-9746-2
dc.identifier.endpageS696en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.pmid21140244en_US
dc.identifier.scopus2-s2.0-84655170130en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageS690en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-010-9746-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18347
dc.identifier.volume28en_US
dc.identifier.wosWOS:000301047200104en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectCarnitineen_US
dc.subjectCisplatinen_US
dc.subjectDrug Toxicityen_US
dc.subjectRenal-Failureen_US
dc.subjectToxicityen_US
dc.subjectNeurotoxicityen_US
dc.subjectTherapyen_US
dc.subjectWr2721en_US
dc.subjectKidneyen_US
dc.subjectInjuryen_US
dc.subjectAgentsen_US
dc.titleProtective effect of L-carnitine versus amifostine against cisplatin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu