Protective effects of royal jelly against testicular damage in streptozotocin-induced diabetic rats

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dc.authoridKARACA, Turan/0000-0002-2500-7781;
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.contributor.authorKaraca, Turan
dc.contributor.authorDemirtas, Selim
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorAyvaz, Suleyman
dc.date.accessioned2024-06-12T10:59:26Z
dc.date.available2024-06-12T10:59:26Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: To examine the effects of royal jelly (RJ) on testicular damage in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Eighteen adult Wistar albino rats were used, 6 in each of the 3 treatment groups: Group A: control, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus RJ (400 mg/kg daily for 4 weeks). Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Four weeks after the onset of diabetes, testicular apoptotic cell death was examined using immunohistochemical staining for caspase-3 and Ki67 staining for localization of proliferative cells. Results: Compared with the control, the body and testicular weights of the RJ-treated and untreated diabetic rats were decreased (P < 0.05). The histopathological examination showed a significant increase in degenerative changes in the seminiferous tubules and in spermatogenesis of the STZ-treated rats. In contrast, the RJ treatment group showed near-normal morphology, in addition to an increased intensity of immunohistochemical staining for Ki67-positive cells. Conclusion: Diabetes induced a significant increase in testicular apoptotic cell death (caspase-3-positive cells). Caspase-3-positive cells were significantly decreased in the STZ plus RJ-treated group compared with the untreated STZ-induced diabetic group (P < 0.05).en_US
dc.identifier.doi10.3906/sag-1311-103
dc.identifier.endpage32en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid25790526en_US
dc.identifier.scopus2-s2.0-84920000752en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage27en_US
dc.identifier.trdizinid211802en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1311-103
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/211802
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20450
dc.identifier.volume45en_US
dc.identifier.wosWOS:000347840000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetesen_US
dc.subjectTestesen_US
dc.subjectApoptosisen_US
dc.subjectProliferationen_US
dc.subjectRoyal Jellyen_US
dc.subjectReproductive Functionen_US
dc.subjectApoptosisen_US
dc.titleProtective effects of royal jelly against testicular damage in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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