Effect of black cumin (Nigella sativa) on cadmium-induced oxidative stress in the blood of rats

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dc.contributor.authorKanter, M
dc.contributor.authorCoskun, O
dc.contributor.authorGurel, A
dc.date.accessioned2024-06-12T11:09:12Z
dc.date.available2024-06-12T11:09:12Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe protective effect of black cumin (Nigella sativa = NS) on cadmium-induced oxidative stress was studied in rats. The rats were randomly divided into three experimental groups: A (conrol), B (Cd treated), and C (Cd + NS treated), each containing 10 animals. The Cd-treated and Cd + NS-treated groups were injected subcutaneously daily with CdCl2 dissolved in isotonic NaCl in the amount of 2 mL/kg for 30 d, resulting in a dosage of 0.49 mg Cd/kg/d. The control group was injected with only isotonic NaCl (2 mL/kg/d) throughout the experiment (for 30 d). Three days prior to induction of CdCl2, the Cd + NS-treated group received a daily intraperitoneal injection of 0.2 mL/kg NS until the end of the study. Cd treatment increased significantly the malondialclehyde levels in plasma and erythrocyte (p < 0.01 and p < 0.05, respectively) and also increased significantly the antioxidant levels (superoxide dismutase, glutathione peroxidase, and catalase) (p < 0.05) compared to the control group. Cd + NS treatment decreased significantly the elevated malondialdehyde levels in plasma and erythrocyte (p < 0.01 and p < 0.05, respectively) and also reduced significantly the enhanced antioxidant levels (p < 0.05). Cd treatment increased significantly the activity of iron levels (p < 0.05) in the plasma compared to the control group. Cd + NS treatment decreased the activity of iron levels (p < 0.05) in the plasma compared to the Cd-treated group. In the control group with no treatment, histology of erythrocytes was normal. In the Cd-treated group, there were remarkable membrane destruction and hemolytic changes in erythrocytes. In the Cd + NS-treated group, these changes were less than in the Cd-treated group. Our results show that N. sativa exerts a protective effect against cadmium toxicity.en_US
dc.identifier.doi10.1385/BTER:107:3:277
dc.identifier.endpage287en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue3en_US
dc.identifier.pmid16286683en_US
dc.identifier.scopus2-s2.0-27844482152en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.1385/BTER:107:3:277
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22723
dc.identifier.volume107en_US
dc.identifier.wosWOS:000233296800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella Sativaen_US
dc.subjectCadmiumen_US
dc.subjectErythrocyteen_US
dc.subjectOxidative Stressen_US
dc.subjectHemolysisen_US
dc.subjectRaten_US
dc.subjectInduced Lipid-Peroxidationen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectAntioxidant Systemen_US
dc.subjectVitamin-Een_US
dc.subjectErythrocytesen_US
dc.subjectToxicityen_US
dc.subjectExposureen_US
dc.subjectCatalaseen_US
dc.subjectDamageen_US
dc.subjectMetallothioneinen_US
dc.titleEffect of black cumin (Nigella sativa) on cadmium-induced oxidative stress in the blood of ratsen_US
dc.typeArticleen_US

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