Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer

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dc.authoridArda, Ersan/0000-0002-5430-6561
dc.authorwosidArikan, Gurkan/AAO-7476-2021
dc.authorwosidakgül, murat/AGE-2468-2022
dc.authorwosidArda, Ersan/L-7357-2016
dc.contributor.authorArda, Ersan
dc.contributor.authorArikan, Gurkan
dc.contributor.authorAkdere, Hakan
dc.contributor.authorAkgul, Murat
dc.contributor.authorYuksel, Ilkan
dc.date.accessioned2024-06-12T11:16:10Z
dc.date.available2024-06-12T11:16:10Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To determine the utility of preoperative complete blood count (CBC) based systemic inflammatory markers in the prediction of testicular cancer and its prognosis. Material and Methods: Between 2008-2017 the data of all testicular tumor patients undergoing radical orchiectomy were retrospectively analyzed. Patient baseseline characteristics (age, tumor stage, tumor markers, etc.) and results of routine preoperative blood tests including mean platelet volume (MPV), red cell distribution width (RDW), lymphocyte ratio (LR) and neutrophil ratio (NR) were retrieved. In addition, neutrophil to lymphocyte ratio (NLR) was calculated. Results: Mean age of the tumor and control group was 36.0 +/- 15 and 30.50 +/- 11 years, respectively. Mean RDW, NR and NLR were significantly higher in the tumor group with p values<0.001; whereas LR and MPV were significantly higher in the control group (p<0.001). Receiver Operating Characteristic (ROC) analyses of LR, NR, RDW, MPV, and NLR are shown in Table-3. The cut off values for RDW and NR were found as 13,7 (Area under the curve (AUC): 0.687, sensitivity = 42.2%, specificity = 84.8%) and 55.3 (AUC:0.693, sensitivity 72.2%, specificity 62%), respectively. Area under the curve for NLR in tumor group was 0.711, with a threshold value of 1.78 and sensitivity=81.8% and specificity= 55.4% (AUC:0.711/sig<0.001) that together with RDW exhibited the best differential diagnosis potential which could be used as an adjuvant tool in the prediction of testicular tumor and its prognosis. Conclusion: Several systemic inflammatory markers, which are obtained by routinely performed cost-effective blood tests, could demonstrate incremental predictive and prognostic information adjuvant to preoperativly achieved testiscular tumor markers.en_US
dc.identifier.doi10.1590/S1677-5538.IBJU.2018.0820
dc.identifier.endpage223en_US
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue2en_US
dc.identifier.pmid32022510en_US
dc.identifier.scopus2-s2.0-85078998795en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage216en_US
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2018.0820
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24202
dc.identifier.volume46en_US
dc.identifier.wosWOS:000530042300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrazilian Soc Urolen_US
dc.relation.ispartofInternational Braz J Urolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTesticular Neoplasmsen_US
dc.subjectNeutrophilsen_US
dc.subjectLymphocytesen_US
dc.subjectTo-Lymphocyte Ratioen_US
dc.subjectPretreatment Neutrophilen_US
dc.subjectDiagnosisen_US
dc.subjectAssociationen_US
dc.subjectSurvivalen_US
dc.titlePredictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular canceren_US
dc.typeArticleen_US

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