Protective effects of Nigella sativa on the neuronal injury in frontal cortex and brain stem after chronic toluene exposure

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:16:28Z
dc.date.available2024-06-12T11:16:28Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe goal of this study was designed to evaluate the possible protective effects of Nigella sativa (NS) on the neuronal injury in the frontal cortex and brain stem after chronic toluene exposure in rats. The rats were randomly alotted into one of three experimental groups: A (control), B (toluene treated) and C (toluene treated with NS); each group contain 10 animals. Control group received 1 ml serum physiologic and toluene treatment was performed by inhalation of 3,000 ppm toluene, in a 8 h/day and 6 day/week order for 12 weeks. The rats in NS treated group was given NS (in a dose of 400 mg/kg body weight) once a day orally by using intra gastric intubation for 12 weeks starting just after toluene exposure. Tissue samples were obtained for histopathological investigation. To date, no histopathological changes of neurodegeneration in the frontal cortex and brain stem after chronic toluene exposure in rats by NS treatment have been reported. In this study, chronic toluene exposure caused severe degenerative changes, shrunken cytoplasma, severely dilated cisternae of endoplasmic reticulum, markedly swollen mitochondria with degenerated cristae and nuclear membrane breakdown with chromatin disorganization in neurons of the frontal cortex and brain stem. The nerve cells showing the pathologic changes were almost absent in the NS-treated rats. We conclude that NS therapy causes morphologic improvement on neurodegeneration in frontal cortex and brain stem after chronic toluene exposure in rats. We believe that further preclinical research into the utility of NS may indicate its usefulness as a potential treatment on neurodegeneration after chronic toluene exposure in rats.en_US
dc.identifier.doi10.1007/s11064-008-9702-0
dc.identifier.endpage2249en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue11en_US
dc.identifier.pmid18427986en_US
dc.identifier.scopus2-s2.0-52549093785en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2241en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-008-9702-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24331
dc.identifier.volume33en_US
dc.identifier.wosWOS:000259483300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTolueneen_US
dc.subjectNigella Sativaen_US
dc.subjectMorphologyen_US
dc.subjectFrontal Cortexen_US
dc.subjectBrain Stemen_US
dc.subjectRatsen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectRatsen_US
dc.subjectMelatoninen_US
dc.subjectHippocampusen_US
dc.subjectEthanolen_US
dc.subjectDamageen_US
dc.subjectOilen_US
dc.subject1,1,1-Trichloroethaneen_US
dc.subjectNeurodegenerationen_US
dc.subjectNeurotoxicityen_US
dc.titleProtective effects of Nigella sativa on the neuronal injury in frontal cortex and brain stem after chronic toluene exposureen_US
dc.typeArticleen_US

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