Frequency of Epstein-Barr virus and human papilloma virus in patients with nasopharyngeal carcinoma

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dc.contributor.authorAltekin, Ilhan
dc.contributor.authorTas, Abdullah
dc.contributor.authorYalcin, Omer
dc.contributor.authorGuven, Selis Gulseven
dc.contributor.authorAslan, Zulkar
dc.contributor.authorAdali, Mustafa Kemal
dc.contributor.authorKarasalihoglu, Ahmet Rifat
dc.date.accessioned2024-06-12T11:09:00Z
dc.date.available2024-06-12T11:09:00Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose Nasopharyngeal cancer is a type of malignancy originating from the epithelial cells lining the nasopharynx. In genetic and environmental factors, infection with Epstein-Barr virus is one of the particular factors held accountable for the etiopathogenesis. Human papillomavirus has been associated with cervical, anogenital, and oropharyngeal cancers. The aim of the present study is to demonstrate the presence and incidence of Epstein-Barr virus and human papillomavirus in patients with nasopharyngeal cancer. Methods The information collected for these patients included age at the time of biopsy, gender, alcohol consumption and smoking, and histopathological type of nasopharyngeal cancer. Only patients for whom nasopharyngeal biopsy was performed as punch biopsy were included in the study. In situ hybridization was performed with formalin-fixed, paraffin-embedded tissue sections for Human Papillomavirus and Epstein-Barr virus nucleic acids obtained by means of automated Ventana BenchMark Medical system Results Utilizing in situ hybridization with samples obtained from 56 patients diagnosed with nasopharyngeal cancer. Epstein-Barr virus was positive in 41 out of the 56 (73.2%) patients, while human papillomavirus was positive in 3 (5.4%), and 1 patient (1.8%) had co-infection. Thirty seven (90.2%) of the 41 patients positive for Epstein-Barr virus were Type-2 according to WHO, while 4 (9.8%) were Type-1. All three patients (100%) with Human Papillomavirus positivity were Type-2 according to WHO. Conclusions This study shows the close association between nasopharyngeal cancer and Epstein-Barr virus whereas such an association is not shown for Human Papillomavirus.en_US
dc.identifier.doi10.1007/s00405-020-05907-x
dc.identifier.endpage2047en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue7en_US
dc.identifier.pmid32170419en_US
dc.identifier.scopus2-s2.0-85081715039en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2041en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-020-05907-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22650
dc.identifier.volume277en_US
dc.identifier.wosWOS:000540235800022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNasopharyngeal Canceren_US
dc.subjectEpstein-Barr Virus Infectionen_US
dc.subjectHuman Papillomavirus Type-16en_US
dc.subjectIn Situ Hybridizationen_US
dc.subjectAssociationen_US
dc.subjectHeaden_US
dc.subjectHpven_US
dc.titleFrequency of Epstein-Barr virus and human papilloma virus in patients with nasopharyngeal carcinomaen_US
dc.typeArticleen_US

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