Importance of Ki-67 in human epidermal growth factor receptor 2 positive breast cancer

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dc.authoridTanriverdi, Ozgur/0000-0002-0598-7284
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.authorwosidTanriverdi, Ozgur/M-2172-2015
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.contributor.authorErdogan, Bulent
dc.contributor.authorTurkmen, Esma
dc.contributor.authorYalta, Tulin Deniz
dc.contributor.authorUsta, Ufuk
dc.contributor.authorKodaz, Hilmi
dc.contributor.authorHacibekiroglu, Ilhan
dc.contributor.authorTanriverdi, Ozgur
dc.date.accessioned2024-06-12T10:55:12Z
dc.date.available2024-06-12T10:55:12Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to evaluate the importance of Ki-67 in Human Epidermal Growth Factor Receptor 2 (Her-2) positive breast cancer patients. Methods: We reviewed the records of patients diagnosed with Her-2-positive non-metastatic breast cancer between 2005 and 2011. Paraffin-embedded tissue samples were stained with MIB-1 mouse monoclonal antibody to find Ki-67 levels. Patients were grouped as low Ki-67 <20% and high Ki-67 >= 20%. Demographic and clinical features were compared. Results: One hundred and six patients were included in the study. Median follow up time was 41 months (range 15-100). Median age was 49.5 years (range 29-79). Twenty-nine patients (27.4%) were in the Ki-67 low group. Demographic features were similar in both groups. Lymphovascular invasion was more frequent in the Ki-67 high group, and hormone receptor (HR) positivity was more frequent in the Ki-67 low group (p=0.03, p=0.03, respectively). Recurrence rate was not significantly different in both groups (p=0.36). T stage (p=0.02), stage (p<0.01), lymphovascular invasion (p=0.02), ER status (p=0.02), and HR status (p<0.01) were related with recurrence. In multivariate analysis, stage and HR negativity were independent factors for recurrence (p<0.01, p=0.01, respectively). Recurrence sites were also similar in both groups. Survival rates at the third year for Ki-67 low group and Ki-67 high group were 94% and 92%, respectively. Conclusion: Her-2 positive patients with low Ki-67 and high Ki-67 had similar demographic and pathologic features except lymphovascular invasion and HR status. HR status was an important factor for disease course. Clinical course was determined by HR status rather than Ki-67.en_US
dc.identifier.endpage736en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue3en_US
dc.identifier.pmid26214624en_US
dc.identifier.scopus2-s2.0-84938689913en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage730en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19338
dc.identifier.volume20en_US
dc.identifier.wosWOS:000358399700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal Of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectHer-2en_US
dc.subjectKi-67en_US
dc.subjectLymphovascular Invasionen_US
dc.subjectHer2 Statusen_US
dc.subjectProliferationen_US
dc.subjectPrognosisen_US
dc.subjectExpressionen_US
dc.subjectProteinen_US
dc.subjectIndexen_US
dc.titleImportance of Ki-67 in human epidermal growth factor receptor 2 positive breast canceren_US
dc.typeArticleen_US

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