Exercise and caloric restriction improve cardiovascular and erectile function in rats with metabolic syndrome

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dc.authoridŞener, Göksel/0000-0001-7444-6193
dc.authoridYakut, Zatiye Ayça Çevikelli/0000-0002-6697-6781
dc.authorwosidSener, Tarik Emre/K-2501-2016
dc.authorwosidŞener, Göksel/AAN-4461-2021
dc.authorwosidYakut, Zatiye Ayça Çevikelli/AAF-7800-2021
dc.contributor.authorCevikelli-Yakut, Zatiye Ayca
dc.contributor.authorOzcelik, Reyhan
dc.contributor.authorCevik, Ozge
dc.contributor.authorSener, Tarik Emre
dc.contributor.authorSener, Goksel
dc.date.accessioned2024-06-12T11:18:47Z
dc.date.available2024-06-12T11:18:47Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to examine the possible benefits of exercise and caloric restriction (CR) on cardiovascular hemodynamics, erectile function, and antioxidant system in metabolic syndrome (MS). Sixty male Spraque-Dawley rats were divided into five groups; control, MS, MS + CR, MS + exercise (EXC), and MS + CR + EXC. To induce MS, 10% fructose solution was applied for 3 months. Thereafter, in CR groups calorie was restricted 40% and in EXC groups swimming was performed for 6 weeks. Body weight, blood glucose, and blood pressure (BP) levels were measured before and after MS induction and at the end of the experiment. After decapitation, tumor necrosis factor (TNF)-alpha, adiponectin (ADP), and plasminogen activator inhibitor (PAI)-1 levels were investigated in blood, oxidative stress parameters were examined in heart, aorta, and corpus cavernosum (CC) tissues. Isometric contraction in isolated tissue bath was studied in aorta and CC tissues. Animals subjected to exercise and CR had decreased BP and blood glucose levels. Impaired contraction-relaxation responses in MS group were improved with exercise and CR. MS-induced increase in TNF-alpha, PAI-1, malondialdehyde (MDA), and decrease in ADP, glutathione (GSH), and superoxide dismutase (SOD) were normalized with exercise and CR. Exercise and CR may be beneficial against changes in cardiovascular hemodynamics caused by MS.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Committee [SAG-C-YLP-090113-0002]en_US
dc.description.sponsorshipThis study was supported by Marmara University Scientific Research Projects Committee with the grant number: SAG-C-YLP-090113-0002.en_US
dc.identifier.doi10.1038/s41443-020-00356-w
dc.identifier.endpage853en_US
dc.identifier.issn0955-9930
dc.identifier.issn1476-5489
dc.identifier.issue8en_US
dc.identifier.pmid33009496en_US
dc.identifier.scopus2-s2.0-85091846166en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage844en_US
dc.identifier.urihttps://doi.org/10.1038/s41443-020-00356-w
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24967
dc.identifier.volume33en_US
dc.identifier.wosWOS:000574730800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofInternational Journal Of Impotence Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectOrgan Damageen_US
dc.subjectNitric-Oxideen_US
dc.subjectMelatoninen_US
dc.subjectPreventionen_US
dc.subjectStressen_US
dc.subjectModelen_US
dc.titleExercise and caloric restriction improve cardiovascular and erectile function in rats with metabolic syndromeen_US
dc.typeArticleen_US

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