Neutrophil to lymphocyte ratio predicts appropriate therapy in idiopathic dilated cardiomyopathy patients with primary prevention implantable cardioverter defibrillator
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Saudi Med J
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: To investigate whether an inflammatory marker of neutrophil to lymphocyte ratio (NLR) predicts appropriate implantable cardioverter defibrillator (ICD) therapy (shock or anti tachycardia pacing) in idiopathic dilated cardiomyopathy (IDC) patients. Methods: We retrospectively examined IDC patients (mean age: 58.3 +/- 11.8 years, 81.5% male) with ICD who admitted to outpatient clinic for pacemaker control at 2 tertiary care hospitals in Ankara and Edirne, Turkey from January 2013-2015. All ICDs were implanted for primary prevention. Hematological and biochemical parameters were measured prior procedure. Results: Over a median follow-up period of 43 months (Range 7-125), 68 (33.1%) patients experienced appropriate ICD therapy. The NLR was increased in patients that received appropriate therapy (4.39 +/- 2.94 versus 2.96 +/- 1.97, p<0.001). To identify independent risk factors for appropriate therapy, a multivariate linear regression model was conducted and age (beta=0.163, p=0.013), fasting glucose (beta=0.158, p=0.017), C-reactive protein (CRP) (beta=0.289, p<0.001) and NLR (beta=0.212, p<0.008) were found to be independent risk factors for appropriate ICD therapy. Conclusions: Before ICD implantation by using NLR and CRP, arrhythmic episodes may be predictable and better antiarrhythmic medical therapy optimization may protect these IDC patients from unwanted events.
Açıklama
Anahtar Kelimeler
C-Reactive Protein, Neutrophil/Lymphocyte Ratio, Ventricular-Arrhythmias, Natriuretic Peptide, Atrial-Fibrillation, Collagen Turnover, Serum Markers, Heart-Failure, Association, Recipients
Kaynak
Saudi Medical Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
38
Sayı
2
