Histopathological and biochemical comparisons of the protective effects of amifostine and L-carnitine against radiation-induced acute testicular toxicity in rats

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authoridArda, Ersan/0000-0002-5430-6561;
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.authorwosidArda, Ersan/L-7357-2016
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorAktoz, T.
dc.contributor.authorCaloglu, M.
dc.contributor.authorYurut-Caloglu, V.
dc.contributor.authorYalcin, O.
dc.contributor.authorAydogdu, N.
dc.contributor.authorNurlu, D.
dc.contributor.authorArda, E.
dc.date.accessioned2024-06-12T10:51:24Z
dc.date.available2024-06-12T10:51:24Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to compare the radioprotective efficacies of amifostine (AMI) and L-carnitine (LC) against radiation-induced acute testicular damage. Thirty Wistar albino rats were randomly assigned to four groups: control (n = 6), AMI plus radiotherapy (RT) (n = 8), LC plus RT (n = 8) and RT group (n = 8). The rats were irradiated with a single dose of 20 Gy to the scrotal field. LC (300 mg/kg) and AMI (200 mg/kg) were given intraperitoneally 30 min before irradiation. The mean seminiferous tubule diameters (MSTDs) were calculated. Testicular damage was evaluated histopathologically using Johnsen's mean testicular biopsy score criteria. Malondialdehyde (MDA) and glutathione levels were measured in tissue samples. AMI plus RT and LC plus RT groups had significantly higher MSTDs than those in the RT group (p =.003 and p =.032 respectively). MDA values of both AMI plus RT and LC plus RT groups were significantly lower than those in RT group (p <.004 and p <.012 respectively). As a result, AMI and LC have a similar radioprotective effect against radiation-induced acute testicular damage, histopathologically and biochemically.en_US
dc.identifier.doi10.1111/and.12754
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue9en_US
dc.identifier.pmid28000945en_US
dc.identifier.scopus2-s2.0-85007346604en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.12754
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18355
dc.identifier.volume49en_US
dc.identifier.wosWOS:000412838200013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmifostineen_US
dc.subjectL-Carnitineen_US
dc.subjectRadiotherapyen_US
dc.subjectTestisen_US
dc.subjectDna Fragmentationen_US
dc.subjectMitochondrial-Functionen_US
dc.subjectHuman Spermatozoaen_US
dc.subjectFlow-Cytometryen_US
dc.subjectMembraneen_US
dc.subjectFunctionalityen_US
dc.subjectGradienten_US
dc.subjectMotilityen_US
dc.subjectProbesen_US
dc.subjectStainen_US
dc.titleHistopathological and biochemical comparisons of the protective effects of amifostine and L-carnitine against radiation-induced acute testicular toxicity in ratsen_US
dc.typeArticleen_US

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