Yazar "Yulugkural, Zerrin" seçeneğine göre listele
Listeleniyor 1 - 15 / 15
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Acute Onset Myositis Associated with Brucellosis, Quite a Rare Diagnosis(Japan Soc Internal Medicine, 2008) Celik, Aygul Dogan; Celik, Yahya; Yulugkural, Zerrin; Balci, Kemal; Utku, UfukBrucellosis is a zoonosis that is transmissible to humans. It is a disease with multi-systemic involvement caused by the genus Brucella. Neurological complications, including meningitis, meningo-encephalitis, myelitis-radiculoneuritis, brain abscess, epidural abscess and meningo-vascular syndromes, are rarely encountered. We present a patient presenting with acute onset myositis. This kind of presentation has not previously been reported in the English language literature. We conclude that the diagnosis of neuro-brucellosis should be considered in patients presenting with muscle weakness.Öğe Candida glabrata: Etiologic agent of soft tissue abscess in a diabetic patient(Wolters Kluwer Medknow Publications, 2010) Celik, Aygul Dogan; Yulugkural, Zerrin; Kuloglu, Figen; Akata, Filiz[Abstract Not Available]Öğe Changes in antimicrobial resistance and outcomes of health care-associated infections(Springer, 2021) Aydin, Mehtap; Azak, Emel; Bilgin, Huseyin; Menekse, Sirin; Asan, Ali; Mert, Habibe Tulin Elmaslar; Yulugkural, ZerrinTo describe the change in the epidemiology of health care-associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%.Öğe Community-Based Seroepidemiology of Diphtheria and Tetanus in Edirne, Turkey(Natl Inst Infectious Diseases, 2009) Tansel, Ozlem; Ekuklu, Galip; Eker, Alper; Kunduracilar, Hakan; Yulugkural, Zerrin; Yuksel, PelinThe aim of this study was to evaluate the seroprevalence and correlates of diphtheria and tetanus in Edirne, Turkey. Tetanus and diphtheria antitoxin levels were determined by enzyme-linked immunosorbent assay. Among 99 participants, a diphtheria antitoxin level of >= 0.1 IU/mL was found in 97 (98%), while 2 (2%) had antitoxin levels of 0.011-0.099 IU/mL. The geometric mean titers (GMTs) in men were statistically higher. Among 295 participants, a tetanus antitoxin level of >= 0.1 IU/mL was found in 291 (98.6%), while 4 (1.4%) had antitoxin levels of 0.011-0.099 IU/mL. Participants who had completed secondary school or higher education showed higher GMT values. Additionally, participants vaccinated within the previous 5 years had higher GMT values and the percentage of participants who had completed secondary school or higher education was higher among them. GMTs decrease with increasing age and increase as the poverty index increases. The average socioeconomic status index of the participants was high for both diphtheria and tetanus seroepidemiology. In this community-based study, antitoxin levels of diphtheria and tetanus were high. However, revaccination of adults with tetanus-diphtheria toxoids at every opportunity (military service, pregnancy, post-injury prophylaxis, etc.) together with a single booster every 10 years should be considered as an immunization policy.Öğe CTX-M Type Extended Spectrum ?-Lactamases in Escherichia coli Isolates From Community Acquired Upper Urinary Tract Infections at a University in the European Part of Turkey(Scientific Communications Int Ltd, 2010) Celik, Aygul Dogan; Yulugkural, Zerrin; Kuloglu, Figen; Eroglu, Cafer; Torol, Sinem; Vahaboglu, Haluk; Akata, FilizExtended spectrum beta-lactamase (ESBL) producing Escherichia coli has been an emerging etiologic agent in the community acquired infections. We investigated the occurrence of ESBL producing E. coli isolated from patients admitted with community acquired urinary tract infection (UTI) to the hospital of the Trakya University, Turkey during 2006. Eleven single patient isolates of E. coli harboring ESBL were identified among 30 E. coli isolated from patients admitted with symptoms corresponding to upper UTI. CTX-M type ESBLs were detected in all 11 ESBL-producers by isoelectric focusing and polymerase chain reaction screening. Sequence analysis revealed CTX-M-1 in one isolate, CTX-M-3 in three isolates and CTX-M-15 in seven isolates. ESBL-producing E. coli isolated from community acquired UTIs are widespread in the European parr of Turkey.Öğe Evaluation of insomnia in healthcare personnel after COVID-19 vaccination(Kare Publ, 2023) Yilmam, Ilker; Kaya, Bilkay Serez; Temelli, Suereyya; Edis, Ebru Cakir; Yulugkural, ZerrinBACKGROUND AND AIM: Sleep disturbances are common during Coronavirus Disease 2019 (COVID-19) infection. Coronasomnia is a concept used to identify sleep disturbances observed during the pandemic. Although coronasomnia has been described during and after coronavirus infection, no data on sleep disturbances seen after vaccinations have been found. The aim of this study was to detect the prevalence of sleep disturbances observed after COVID-19 vaccinations (specifically CoronaVac).METHODS: In April 2021, healthcare personnel who had received the CoronaVac vaccine were administered questionnaires to investigate potential adverse effects of the vaccine and any sleep disturbances. RESULTS: The study included 787 individuals, of whom 506 (64.3%) were women. The mean age was 35 +/- 9.6 (19-65) years. 303 (38.5%) healthcare workers reported adverse effects after vaccination. The most common adverse effects were exhaustion, muscle pain, and headache. At least one sleep disturbance (difficulty falling asleep, frequent awakening, difficulty maintaining sleep, excessive daytime sleepiness, and need to use sleeping pills) that did not exist before vaccination but occurred afterwards was found in 86 (10.9%) participants. Women had higher insomnia scores than men (p=0.02). An important result of the study is that the insomnia scores of healthcare workers who had COVID-19 are statistically higher than those who did not (p=0.02).CONCLUSIONS: Adequate sleep is important for both protection from infection and the immune response against infection. Although coronasomnia developing after the COVID-19 variant that was identified at the beginning of the pandemic is well-defined, we believe that effects such as sleep disorders that may develop after vaccination should be monitored in the long term and in a large population.Öğe Evaluation of the flu vaccine administered to health care workers in Trakya University Hospital in 2006(Ankara Microbiology Soc, 2008) Kuloglu, Figen; Celik, Ayguel Dogan; Yulugkural, Zerrin; Erkan, Tuelay; Keskin, Serap; Akata, FilizAfter the detection of human cases of highly pathogenic avian influenza A (H5N1) virus in Eastern Turkey in January 2006, Turkish Ministry of Health has had declared National Plans of Activity for Pandemic Influenza. All health-care facilities were recommended to develop contingency plans. Then the essential activities were started in August 2006 in Trakya University, Faculty of Medicine (Edirne, Trace region of Turkey), and institutional education about pandemic influenza and preventive measures was implemented to health care workers (HCWs). In November 2006, health care workers were offered inactivated flu vaccine (Vaxigrip, Sanofi Pasteur, France) supplied by the Ministry of Health. The aim of this questionary survey was to evaluate the visions and conceptions of health care workers about influenza vaccination during the vaccination campaign. All the participants were informed by using an information form including the indications, contraindications and possible adverse reactions of flu vaccine, and were requested to complete the questionnaire about influenza vaccination according to their own perception before vaccination. Vaccine recipients were also invited to the vaccination unit if they had any adverse reaction. A total of 1041 HCWs (560 female, 481 male; mean age: 32.8 +/- 8.2 years) completed the questionnaire. Of them 884 subjects (85%) have accepted to be vaccinated, while 157 subjects (15%) have not. It was determined that 72 HCWs (6.9%) had been administered flu vaccine in 2005, and 38 (3.7%) have had an underlying chronic disease requiring medical therapy. Six subjects (16%) with an underlying chronic disease were vaccinated in 2005, while 66 HCWs (6.6%) without any chronic disease received vaccination voluntarily. Seven workers (0.7%) declined vaccination as they defined hypersensitivity to egg, and 84 workers (8%) had influenza vaccine voluntarily before the campaign in 2006. Sixty six workers (6.3%) have refused to be vaccinated as they considered influenza vaccination ineffective to protect against flu. Two workers (0.2%) had allergic skin reactions such as erythema and itching after vaccination. It can be concluded that influenza vaccination of the health care workers is a part of infection control policies and it is also a matter of patient safety. The implementation of necessary education programmes and attempts to emphasize the importance of vaccination of health care workers especially dealing with high risk patients, would be of crucial importance to decrease the morbidity and mortality due to influenza infections.Öğe HEPATITIS E VIRUS EPIDEMIOLOGY IN ADULT POPULATION IN EDIRNE PROVINCE, TURKEY(Ankara Microbiology Soc, 2009) Eker, Alper; Tansel, Oezlem; Kunduracilar, Hakan; Tokuc, Burcu; Yulugkural, Zerrin; Yusel, PelinHepatitis E virus (HEV) clinical presentations range from asymptomatic infection to fulminant hepatitis which is frequently seen in pregnant women. Epidemics due to HEV mostly originate from contaminated water and the virus is transmitted by fecal oral way. Its frequency is closely related to the socioeconomical status of the community. The aim of this first community-based study performed in Edirne province (located at Trace region of Turkey) was to determine the seroprevalence of HEV and the risk factors in the city center. Five hundred eighty two people (273 men, 309 women) over age 15 years, representing the population of Edirne city center were included in the study. Anti-HEV IgG antibodies were investigated in the serum samples by ELISA method. Anti-HEV antibodies were detected in a total of 14 cases (11 women, 3 men) and HEV infection prevalence was found to be 2.4%. The mean age of seropositive people was 50.86 +/- 16.76 years while it was 40.7 +/- 16.9 years in seronegative people (p= 0.027). This result was attributed to the better water supply and sanitation conditions in Edirne province in comparison to other parts of Turkey and shift of HEV seropositivity in older ages. No statistically significant difference was detected between seropositive and seronegative cases in terms of socioeconomical conditions, both groups being in high socioeconomical level. The analysis of the risk factors revealed that the rate of people living in houses built with materials other than reinforced concrete (p= 0.044), dealing with stockbreeding (p= 0.046) and consuming fruits and vegetables without proper washing (p= 0.015) were significantly higher in the seropositive group. No statistically significant difference was detected for the other risk factors such as the number of household, presence of city water supply and sewage system in the house, location of the water closet outside house, lack of hand-washing habits, sharing utensils, consumption of raw vegetables, history of blood transfusion, surgery, dental intervention, jaundice, contact with a case of hepatitis, abortion/stillbirth and suspicious sexual contact. While the HEV seropositivity rate (2.4%) detected in Edirne was lower than the average of Turkey (6%), it was similar to the results reported from western part of the country. High rates of seropositivity among people with individual incompatibility to the hygiene rules denotes that personal hygiene is an important factor for prevention from HEV infection. High rate of seropositivity among people dealing with stockbreeding also suggests that there may be different ways of HEV transmission other than contaminated water in sporadic cases.Öğe Negative serology: could exclude the diagnosis of brucellosis?(Springer Heidelberg, 2012) Celik, Aygul Dogan; Yulugkural, Zerrin; Kilincer, Cumhur; Hamamcioglu, Mustafa Kemal; Kuloglu, Figen; Akata, FilizTwo cases of brucellar spondylodiscitis of the lumbar area were presented. Although both cases showed typical radiological changes, serological tests could not detect Brucella agglutinating antibodies. One of the patients was bacteremic and Brucella spp. was identified from blood culture. In the second patient needle biopsy was required for definite diagnosis. Although small, serologic tests have a certain rate of false negative results in brucellosis. Thus, a negative serology should not exclude the diagnosis of brucellosis, as it is demonstrated in the current cases.Öğe Neutropenic enterocolitis(Aves Yayincilik, Ibrahim Kara, 2007) Yulugkural, Zerrin; Uckardes, Huseyin; Mutlu, Birsen; Hacihanefioglu, AbdullahNeutropenic enterocolitis is an acute syndrome characterized by cecal and ascending colon inflammation that may progress to necrosis and perforation. It is most often associated with leukemia but has also been described in patients with solid tumors, multiple myeloma, aplastic anemia, AIDS, and cyclic neutropenia. Twenty-five year old male patient was admitted with a diagnosis of acute myeloid leukemia. Severe fever, abdominal sensitivity and severe pain and diarrhea with blood developed in the patient treated idarubicin and cytosine arabinoside. Direct abdominal radiogram revealed air-fluid levels, the patient was diagnosed as typhlitis and taken to an emergency operation in which the necrotised small bowel was resected. Severe abdominal pain and sensitivity, diarrhea with blood and thrombocytopenia developed again on the 19th day on which the patient was reoperated. Ileal resection and colostomia was performed on this second operation. Thrombocytopenia, prolonged bleeding and coagulation times and gastrointestinal bleeding was observed. Despite all treatment efforts, the patient developed tachycardia, tachipnea, cognitive changes and sepsis and died.Öğe Retrospective evaluation of the cases prediagnosed as viral encephalitis in Trace University Hospital between the period of 2000-2005(Ankara Microbiology Soc, 2008) Yulugkural, Zerrin; Celik, Ayguel Dagan; Celik, Yahya; Kuloglu, Figen; Bueyuekkoyuncu, Nlluefer; Tansel, Oezlem; Akata, FilizIn this study, a total of 17 adult patients (( :18 years old; 12 male, 5 female) with encephalitis followed up in neurology and infectious diseases clinics of Trace University Hospital between the years 2000-2005 were retrospectively analyzed. The most common signs and symptoms were confusion (n: 13; 76.4%), nausea and vomiting (n: 13; 76.4%), disorientation (n: 12; 70%), fever and headache (n: 11; 64.7%), amnesia (n: 10; 58.8%), convulsions (n: 9; 52.9%), agitation (n: 7; 41%), dysphasia and aphasia (n: 6; 35.2%), nuchal stiffness (n: 5; 29.4) and focal neurological signs (n: 1; 5.8%). Six of the patients were admitted to the hospital during summer, six during winter, four during spring and one during autumn. Eleven (64.7%) of the patients had electroencephalographic signs compatible with encephalitis. Encephalitis related signs were detected in 83.3% (10/12) of the patients by cranial magnetic resonance imaging and in 58.3% (7/12) by computerized tomography. Cerebrospinal fluid (CSF) examination revealed low glucose levels in 17.6% (3/17), high protein levels in 47% (8/17) and increased white blood cells with a predominance of lymphocytes in 41.2% (7/17) of the cases. CSF findings were within normal limits in 23.5% (4/17) of the patients. Empirical acyclovir treatment was given to all patients. One patient died at the acute phase of the infection while all the other 16 recovered. Since none of the CSF samples yielded bacterial growth, all of the patients were diagnosed as viral encephalitis. However, no investigation was performed to identify the viral etiology and this was the major limitation owing to the inadequacy of laboratory facilities during the study period and/or unawareness of the physicians about viral identification methods.Öğe Seroepidemiology of Toxoplasmosis and the Theoretical Incidence of Congenital Toxoplasmosis in Women of Reproductive Age in Edirne, Turkey. A Community Based Study(Ortadogu Ad Pres & Publ Co, 2009) Tansel, Ozlem; Ekuklu, Galip; Kunduracilar, Hakan; Eker, Alper; Yulugkural, Zerrin; Yuksel, PelinObjective: The aims of this community-based study were to determine the seroprevalence of toxoplasmosis in women of reproductive age, to identify the risk factors, and to estimate theoretical incidence of congenital toxoplasmosis in Edirne city center. Material and Methods: Sera from 96 women representing the female population in the city center were tested for toxoplasma IgG antibody using the ELISA technique, For each participant, a questionnaire was completed to provide information on socio-demographic data, obstetrical history, and life style parameters. The relation between toxoplasma positivity and probable risk factors was investigated with chi-square and independent samples t test during statistical analysis. Results: The ages of the study population ranged from 15 to 49 years with a mean age of 31.2 years. 33 (34.4%) of 96 women were positive for toxoplasma IgG antibody. The mean age of women with seropositive samples was 34.2 +/- 10.4 years. The mean age of seronegative women was 29.7 +/- 9.2 years. Although the mean age was higher in seropositive women when compared with seronegative, the rates of seropositivity were not significantly different between age groups (p = 0.246). Toxoplasma seropositivity was 85.7% for women with high income and 100% for women with low income. This difference was statistically significant (p = 0.025). The other risk factors were not significantly different between seropositive and seronegative cases. The mean theoretical incidence of congenital toxoplasmosis was 0.7% in our study and it decreased from 1.3% to 0.2% as the person aged. Conclusion: Approximately two out of every three reproductive age women in Edirne city center is at risk of toxoplasmosis. The risk of congenital toxoplasmosis is higher for babies of women aged 15-24 years. These results underline the necessity of promoting preventive measures for toxoplasmosis in reproductive age women.Öğe STAPHYLOCOCCUS AUREUS HEPATIC ABSCESS ASSOCIATED WITH CERVICAL LYMPHADENITIS(Ankara Microbiology Soc, 2009) Celik, Ayguel Dogan; Yulugkural, Zerrin; Kuloglu, Figen; Akata, FilizPyogenic liver abscesses usually develop secondary to biliary tract and intraabdominal infections and members of the Enterobacteriaceae family are usually implicated as the etiologic agents. In this report a case of hepatic abscess devoloped secondary to cervical lymphadenitis caused by Staphylococcus aureus, was presented. Twenty-one years old male patient was admitted to the hospital with complaints of fever, swelling and pain at the right side of the neck and difficulty in swallowing. Physical examination revealed painful submandibular lymphadenopathy with hyperemia. Upon demonstration of cystic lymphadenopathy by magnetic resonance imaging of the neck, the mass was aspirated. Gram-positive cocci with abundant leucocytes were detected in Gram stained smears of the aspiration material and methicillin-susceptible S.aureus (MSSA) was identified in the culture. Treatment with ampicillin/sulbactam (4 x 1.5 g/day) was initiated. However, since patient still had fever and abdominal pain, nausea and vomitting were also added to his complaints, abdominal ultrasonography and computerized tomography (CT) were done and abscesses were demonstrated in liver. The abscesses were drained under CT guidance and the fever of the patient resolved. Treatment with ampicillin/sulbactam was continued for 6 weeks. Although it was considered that the hematogenous spread of MSSA that led to cervical lymphadenitis caused the hepatic abscesses, the agent was neither isolated from the blood culture nor from the hepatic abscess material. It should always be taken into consideration that liver abscesses might accompany distant infections and antibiotic therapy alone might not be sufficient for the complete resolution of such infections.Öğe Susceptibility of escherichia coli strains isolated from urine cultures to some commonly used antibacterial agents(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2007) Yulugkural, Zerrin; Mutlu, BirsenObjectives: The present study was designed to determine the bacteria causing urinary tract infections (UTI) in our hospital and their susceptibility to various antibiotics. Study Design: Susceptibility of 259 uropathogen Escherichia Coli (E.Coli) isolates from urine samples of patients treated in the wards and intensive care units or in the outpatient clinics of our hospital between March 2004 and February 2005, to ampicillin, amoxycillin-clavulanate, gentamicin, ceftriaxone, ofloxacin, ciprofloxacin, co-trimoxazole, and naliclixic acid, the most commonly used antibiotics in UTI, Were evaluated. Among the isolated strains, 63 were from nosocomial and 196 were from community acquired UTI. Identification and susceptibility of strains were determined by an automatized VITEK-1 panel (Biomerieux, France). Results: Comparison of antibiotic susceptibility rates between nosocomial and community-acquired UTI revealed the following results: ampicillin 63-32%, amoxycillin-clavulanate 78-58%, gentamicin 89-83%, ceftriaxone 94-89%, ofloxacin 82-59%, ciprofloxacin 81-54%, cotrimoxazole 71-47%, naliclixic acid 86-64%, nosocomial and community-acquired UTI, respectively. Conclusion: In our opinion, for our region, ciprofloxacin would be the appropriate option for ampiric therapy in patients with probable community-acquired UTI and ampiric parenteral treatment with ceftriaxone would be the appropriate first option in patients with probable nosocomial UTI.Öğe Two cases of brucellosis presented with hepatic and muskulatesklatal system involvement(Aves Yayincilik, Ibrahim Kara, 2007) Yulugkural, Zerrin; Akhan, SilaBrucellosis is a multisysternic infection that is endemic in some parts of the world. Gastrointestinal system involvement is common and the liver is the most frequently affected organ in this system. Musculoskeletal involvement is also common in this disease. In this article, we present two cases of brucellosis presenting with acute cholangitis, and long-term migrating arthritis.
