Yazar "Yoruc, Zeliha" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Synthesis and Biological Activity of a New Pt(II) Complex Involving 4-bromo-2,6-bis-hydroxymethyl-phenol and Nicotinamide
    (Jihad Daneshgahi, 2022) Altun, Ozlen; Yoruc, Zeliha; Boz, Mesut
    In the present study, a Pt(II) complex including 4-Bromo-2,6-bis-hydroxymethylphenol (BBHMP) and nicotinamide (NA) was synthesized and structurally analyzed by using spectral and thermal analysis methods. BBHMP and its Pt(II) complex in the presence of BBHMP and NA were investigated for their antimicrobial, cytotoxicity, gene expression, and antioxidant properties. The antimicrobial activity results showed that the platinum complex displayed a significant effect against Staphylococcus aureus and Candida albicans. The cytotoxicity of BBHMP and platinum complex were determined against human prostate adenocarcinoma (DU145) and breast (MCF7) cancer cell lines by applying the MTT assay. Cytotoxicity results suggested that the Pt(II) complex exhibited moderate cytotoxicity against the growth of these cancer cell lines when compared with the reference drug cisplatin is more effective than free BBHMP and NA. Gene expression results proved that the Pt(II) complex is a special bioactive chemical constituent and potential anticancer agent. The results obtained showed that the complex had highly inhibitory effects on gene expression. In addition, Pt(II) complex also displayed effective antioxidant activity.
  • Küçük Resim Yok
    Öğe
    Synthesis, spectral analysis, and thermodynamic parameters of gold(III) complex in the presence of 4-bromo-2,6-bis(hydroxymethyl)phenol and m-nitroaniline
    (Springer Wien, 2019) Altun, Ozlen; Yoruc, Zeliha
    In the present study, we synthesized 4-bromo-2,6-bis(hydroxymethyl)phenol (BBHMP), and a gold(III) complex was synthesized in the presence of BBHMP and m-nitroaniline (m-NA). The synthesized complex was characterized using spectral (mass, UV-Vis, FT-IR, H-1 NMR, C-13 NMR) and thermal measurements (TG-DTA). The results showed that the optimum conditions for the reactions are pH 7, lambda = 412 nm and the mole ratio of BBHMP:m-NA:Au3+ is 1:1:1. The reaction of BBHMP and m-NA with Au(III) was found to be a complexation reaction and one BBHMP molecule and one m-NA molecule react with one Au(III) molecule. Additionally, the equilibrium constant (K), Gibbs free energy (Delta G), enthalpy (Delta H), and entropy (Delta S) were calculated at 298.16 and 313.16 K, respectively. According to the thermodynamic parameters, the reaction was exothermic because of the decrease in entropy and it was a non-spontaneous process. [GRAPHICS] .