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    Arterial distensibility in Wegener's granulomatosis
    (Turkish Soc Cardiology, 2007) Yildiz, Mustafa; Soy, Mehmet; Kueruem, Turhan; Yildiz, Banu Sahin
    Objective: The purpose of this study was to test the hypothesis; that chronic inflammation may impair vascular function and lead to an increase of arterial pulse wave velocity (PWV) in patients with Wegener's granulomatosis (WG). Methods: We recruited 5 patients with WG and 5 healthy age and sex matched controls in this cross-sectional case-controlled study. Aortic PWV was determined by using an automatic device (Complior Colson, France), which allowed on-line pulse wave recording and automatic calculation of PWV. Results: The carotid-femoral (aortic) PWV was increased in patients with WG as compared with control group (p=0.04). Although we found positive correlation between MAN and heart rate (r=0.75, p=0.01), we did not find any significant correlation between PWV and anthropometric and other hemodynamic parameters (p>0.05). In addition, we found positive correlation between PWV and erythrocyte sedimentation rate in patients with WG (r=0.90, p=0.03). Conclusion: Pulse wave velocity is increased and arterial distensibility decreased in patients with WG. Measurements of carotid-femoral (aortic) PWV may provide an easy and noninvasive technique to identify patients at increased risk of arterial disease.
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    INCREASED ARTERIAL STIFFNESS MEASURED BY CAROTID FEMORAL (AORTIC) PULSE WAVE VELOCITY IN PATIENTS WITH INACTIVE BEHCET'S DISEASE
    (Russian Heart Failure Soc, 2020) Agus, Hicaz Zencirkiran; Yildiz, Banu Sahin; Kahraman, Serkan; Kalkan, Kubra; Aladag, Nazire Baskurt; Yildiz, Mustafa
    Introduction Behcet's disease (BD) is a chronic, multisystemic disease characterised by vascular involvement. Acute and chronic inflammatory processes associated with BD may cause endothelial dysfunction, which can then lead to a subsequent increase of arterial stiffness and altered pressure wave reflections. The aim of this study was to evaluate the pulse wave velocity (PWV) measurements in patients with inactive BD and control subjects. Methods We studied 50 patients with inactive BD and 49 healthy control subjects without known cardiovascular disease. Carotid-femoral PWV was determined in all subjects by the same expert research clinician using Complior device (Colson, Paris, France). Results Mean disease duration was 3.23 +/- 2.31 years. Patients with BD (mean age 36.04 +/- 9.94 years) had significantly higher PWV levels compared to controls (9.57 +/- 1.88 vs. 8.47 +/- 1.13 m/s; p=0,003). PWV was found to be positively correlated with age, systolic, diastolic, mean blood pressure, waist, and waist/hip ratio. Conclusion In our study we demonstrated that patients with BD exhibit significantly increased arterial stiffness assessed by increased carotid-femoral PWV compared to healthy control subjects.