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    Association of MG53 with presence of type 2 diabetes mellitus, glycemic control, and diabetic complications
    (Public Library Science, 2023) Andac, Burak; Ozgun, Eray; Bulbul, Buket Yilmaz; Colak, Serpil Yanik; Okur, Mine; Yekdes, Ali Cem; Ocal, Eftal
    ObjectivesMitsugumin 53 (MG53) is a myokine that acts as a membrane repair protein in tissues. Data on the effect of MG53 on insulin signaling and type 2 diabetes mellitus (T2 DM) are still unknown; most are from preclinical studies. Nevertheless, some researchers have argued that it may be a new pathogenic factor, and therapies targeting MG53 may be a new avenue for T2 DM. Our study aims to evaluate the relationship of circulating MG53 levels with the presence of diabetes, diabetic complications, and glycemic control.MethodsWe conducted a case-control study with 107 patients with T2 DM and 105 subjects without insulin resistance-related disease. Concurrent blood samples were used for serum MG53 levels and other biochemical laboratory data. MG53 concentration was measured using Human-MG53, an enzyme-linked immunosorbent assay kit (Cat# CSB-EL024511HU).ResultsWe found no difference in MG53 levels between the diabetic and control groups (p = 0.914). Furthermore, when the subjects were divided into tertiles according to their MG53 levels, we did not find any difference between the groups in terms of the presence of diabetes (p = 0.981). Additionally, no correlation was observed between weight, BMI, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, HbA1c, albumin excretion in the urine, e-GFR levels, and MG53. Finally, MG53 levels were similar between the groups with and without microvascular and macrovascular complications of diabetes.ConclusionOur research finding provides insightful clinical evidence of lack of association between the levels of MG53 and T2 DM or glycemic control, at least in the studied population of Turkeys ethnicity. However, further clinical studies are warranted to establish solid evidence of the link between MG53, insulin resistance and glycemic control in a wider population elsewhere in the world.
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    Chronic Obstructive Pulmonary Disease and Lung Cancer Mortality Attributed to Air Pollution in Turkiye in 2019
    (Taiwan Assoc Aerosol Res-Taar, 2023) Yekdes, Didem Han; Yekdes, Ali Cem; Celikkalp, Ulfiye; Serin, Pelin Sari; Caglayan, Mirac; Ekuklu, Galip
    Approximately seven million premature deaths occurred due to several health problems caused by air pollution. In this study, we aimed to calculate the mortality rates of lung cancer and Chronic Obstructive Pulmonary Disease (COPD) attributed to PM2.5 in Turkiye in 2019. The universe of the research consists of the entire Turkiye region. Air quality data was obtained from the official website of the Ministry of Environment, Urbanization and Climate Change of the Republic of Turkiye. Lung cancer and COPD mortality data were collected from the official website of the Turkish Statistical Institute by a special request. Mortality rates attributed to PM2.5 were calculated with the WHO AIRQ+ program, and the monthly percent change (MPC) in air pollution level was computed by the JP regression method. The annual average values of PM2.5 and PM10 for 2019 in Turkiye were calculated to be 28.82 mu g m(-3) and 48.08 mu g m(-3), respectively. The mortality rate attributed to PM2.5 for lung cancer is 15% whereas the mortality rate attributed to PM2.5 for COPD is 22%. Except two Nomenclature d'Unites Territoriales Statistiques (NUTS) regions (TR1, TR7) all other regions have statistically significant one joinpoint. As a conclusion, the PM2.5 average values for 2019 in Turkiye are over the limits for both the national legislation and the World Health Organization (WHO). Taking precautions to control air pollution sources and determination of legitimate national PM2.5 limits should be prioritized. Thus, one out of every six deaths from lung cancer and one out of every five deaths from COPD can be prevented.
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    Relationship between the Size and Location of the Mass and Hilar and Mediastinal Lymph Node Metastasis in Early and Locally Advanced Non-small Cell Lung Cancer
    (Coll Physicians & Surgeons Pakistan, 2020) Kuzucuoglu, Mustafa; Gokyer, Ali; Kula, Osman; Yekdes, Ali Cem; Sunal, Baran Serdar; Karamustafaoglu, Yekta Altemur; Yoruk, Yener
    Objective: To determine whether there is a relationship between the size and location of the mass and lymph node metastasis in non-small cell lung cancer. Study Design: Observational study. Place and Duration of Study: Department of Medical Oncology of Trakya University, from November 2013 to November 2018. Methodology: Records of 112 patients, who were followed up for non-small cell lung cancer, were retrospectively reviewed. Patients with distant organ metastasis (M1) and distant lymph node metastasis (N3), a previous history of malignancy, synchronous or metachronous tumors, and those for whom required data could not be obtained were excluded. Lymph nodes were evaluated according to pathology reports in patients undergoing invasive procedures. In patients without invasive procedures, lymph node larger than 1 cm in thorax CT, SUV above 2.5 in PET, and acceptance of metastasis at the Oncology Council was considered decisive. Diameter of the tumor, the shortest distance between the tumor and the mediastinum, the shortest distance between the tumor and the hilum, and the diameters of the largest mediastinal or hilar lymph nodes were measured from the thoracic computed tomography (CT) taken at the time of the diagnosis. The relationship between these values and lymph node metastasis was statistically evaluated. Results: Upon consideration of thoracic CT measurements, lymph node metastasis was found to have a statistically significant relationship with tumors with a large diameter (>55 mm) (p<0.001), tumors close to the mediastinum (<7 mm) (p=0.003), and tumors close to the hilum (<60 mm) (p=0.045). The evaluation of the distinctiveness of markers in diagnosis through ROC analysis showed AUC of 0.70 (p<0.001) for the largest tumor diameter, and the risk of lymph node metastasis was higher for lesions above 55 mm. Conclusion: In thorax CT, Large tumor size, tumor close to mediastinum, tumor close to hilum, large lymph node, and high SUV value of lymph node in PET-CT are associated with increased chances of metastasis.