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  • Küçük Resim
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    Case Report: An Epididymal Abscess Which Imitates Epididiymal Tumor Radiologically and Clinically
    (Trakya Üniversitesi, 2016) Koç, Elif Sitre; Özdemir, Yavuz; Çek, H. Mete; Yalta, Tülin Deniz
    Aims: Testicular and extratesticular masses can be found in scrotum. Although most of those masses are intratesticular, some develop from paratesticular tissues. In this case report, we analyzed the results of a patient admitted to the hospital complaining of a scroted mass causing pain. Case Report: Epididymectomy was performed to a 5-year-old man patient with an expanding scrotal mass which was causing pain. After running some tests, performing initial investigations like scrotal ultrasound scan and MR, there were still doubts about the risk of malignancy. To be sure about the mass whether it is a tumor or an infection, epididymectomy was decided to be performed. The day after the operation, the patient was discharged with no complications. His complaints eased after the operation. Conclusion: The scrotum is the sac that contains the testicles. A scrotal mass can be originated from testicles or paratesticular tissues. Although 3% of all solid extratesticular masses are malignant, previous studies have shown that the malignancy rate can raise up to 16%. That’s why scrotal masses which are not certainly benign must not be ignored and epididymectomy should be performed.
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    Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:
    (2013) Hatipoğlu, Ahmet Rahmi; Oğuz, Serhat; Gürcan, Şaban; Yalta, Tülin Deniz; Albayrak, Doğan; Erenoğlu, Cengiz; Sezer, Yavuz Atakan
    Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced. .Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design:Animal experimentation.Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day. Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively). Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.
  • Küçük Resim
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    Comparison of sirolimus and colchicine treatment on the development of peritoneal fibrozis in rats having peritoneal dialysis
    (2015) Sağıroğlu, Tamer; Sayhan, Mustafa Burak; Yağcı, Mehmet A.; Yalta, Tülin Deniz; Sağıroğlu, Gönül; Çopuroğlu, Elif; Oğuz, Serhat
    Background: Continuous ambulatory peritoneal dialysis is a successful treatment modality for patients with end-stage renal disease. Peritoneal fibrosis (PF) is the most critical complication of long-term peritoneal di- alysis (PD). Aims: In our study, we aimed to compare the effects of colchicine and sirolimus on PF induced by hypertonic peritoneal dialysis solutions in rats. Study Design: Animal experiment. Methods: Twenty-four rats were randomly divided into three groups. The control group received an intraperitoneal injection (ip) of saline. The sirolimus group received the PD solution, plus 1.0 mg/kg/day Rapamune®. The colchicine group received the PD solution ip plus 1.0 mg/kg/day of colchicine. Blood sam- ples were taken to measure the serum levels of VEGF, TGF-β, and TNF-α. Peritoneal tissue samples were taken for histopathological evaluation. Results: TGF-β and TNF-α values in the sirolimus group were found to be statistically significantly lower than in the control and colchicine groups, but the differences between the control and colchicine groups were not statistically significant. No statistically significant differences were found between the groups regarding the VEGF values. Vascular neogenesis and peritoneal thickness were compared; the values in the sirolimus group were statistically reduced compared to the values in the control group. Mild fibrosis developed in 75% of all animals in the sirolimus group; there was no moderate or severe fibrosis observed. Fibrosis developed to varying degrees in 100% of the animals in the control and colchicine groups. Conclusion: The present study demonstrates that sirolimus might be beneficial for preventing or delaying the progression of PF and neoangiogenesis. These alterations in the peritoneal membrane may be connected with reduced TNF-α and TGF-β levels.