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Öğe CUTANEOUS INFECTION CAUSED BY ALTERNARIA ALTERNATA IN AN IMMUNOCOMPETENT HOST(Ankara Microbiology Soc, 2009) Guercan, Saban; Piskin, Sueleyman; Kilic, Haluk; Temelli, Baksel Ay; Yalcin, OemerHuman infections caused by Alternaria alternata are more frequently reported in immunosupressive hosts. In this report, a rarely seen cutaneous infection, caused by A.alternata in an immunocompetent patient was presented. The patient (71 years-old, male) was admitted to the dermatology unit with complaints of an erythematous and squamatous lesion of 5 cm diameter on left malleolar region. The case was evaluated as immunocompetent based on the normal serum total immunoglobulin and complement levels, anti-HIV negativity, and no known underlying disease. A number of Alternaria spp. conidia and hypha were seen in the microscopical examination of KOH treated cutaneous scrapings of the lesion obtained in two different days. Fungal cultures of the skin scrapings yielded the growth of a fungus identified as A.alternata. Although fungal elements were not detected in haematoxylene-eosin stained smears of the skin biopsy, A.alternato was again isolated in the culture of the biopsy specimen. The identification of the fungus was confirmed by a reference center (Mycology Section of Scientific Institute of Public Health, Belgium) and it was integrated to BCCM/IHEM collection under accession number IHEM 22598. Antifungal susceptibility test efforts failed due to a problem in the preparation of fungal suspension. Oral itraconazole (200 mg/day) and bifonazole cream was used for the treatment and the lesion regressed after the 19(th) day of the therapy. The treatment was continued with oral and local terbinafine for two weeks and the patient fully recovered. Since A.alternata was demonstrated both in the skin scrapings and tissue biopsy through microscopic examination and culture, it was evaluated as the causative agent of skin infection rather than colonization. This was the first A.alternato infection in an immunocompetent patient in the light of the current literature.Öğe Eruptive Syringoma(Ortadogu Ad Pres & Publ Co, 2009) Arican, Oezer; Yalcin, Oemer; Kuru, Sezin[Abstract Not Available]Öğe Evaluation of Surgical and Histopathologic Results of Patients Operated for Parotid Gland Tumor(Aves Yayincilik, Ibrahim Kara, 2009) Tas, Abdullah; Giran, Safiye; Yagiz, Recep; Yalcin, Oemer; Koten, Muhsin; Adali, Mustafa Kemal; Karasalihoglu, AhmetObjectives: To investigate the patients with parotid tumors retrospectively and to evaluate the surgical procedure, histopathologic results, incidence, follow-up time and complications. Patients and Methods: The study included 56 patients (38 males, 18 females; mean age 52.7 years; range 7 to 86 years) who presented with a mass below or in front of the ear between January 2000 and May 2008. The data regarding patient age, sex, surgical procedure, postoperative histopathologic results and follow-up time were recorded. Results: One of the male patients underwent operation twice because of the bilateral parotid mass. According to the postoperative histopathologic results, 37 of the cases were benign (64.9%), and 20 of them were malign (35.1%). Pleomorphic adenoma (13 patients) and Whartin tumor (13 patients) incidence were similar. Partial superficial parotidectomy, superficial parotidectomy, and total parotidectomy were performed. In addition, some of the patients underwent neck dissection. The most frequent complication was transient facial nerve paresis. Conclusion: For the management of benign parotid gland tumors, superficial or partial superficial parotidectomy is a sufficient surgery. For malign tumors, superficial or total parotidectomy; in cases with neck masses, neck dissection; and in cases involving the facial nerve, facial nerve resection and reconstruction should be performed. According to the type of tumor, postoperative radiation therapy and chemotherapy should be performed as well.Öğe Inflammatory fibroid polyp(Aves Yayincilik, Ibrahim Kara, 2008) Ilgili, Ayseguel; Usta, Ufuk; Ozpuyan, Fulya; Yalcin, OemerInflammatory fibroid polyp is a rare benign lesion that most frequently originates from the gastric antrum, but can also be seen in any part of the gastrointestinal tract. Differential diagnosis includes gastrointestinal polyps and polypoid stromal tumors due to their polypoid appearance on gross examination, and microscopically, various malignant and benign stromal tumors, primarily gastrointestinal stromal tumors. We presented a 51-year-old female patient who was referred to our center with a diagnosis of adenocarcinoma made after an endoscopic biopsy, but found to have an inflammatory fibroid polyp located in the antrum after distal subtotal gastrectomy.Öğe Multiple Red-Brown Macules in Legs of a Child(Ortadogu Ad Pres & Publ Co, 2010) Piskin, Sueleyman; Arican, Oezer; Uzunali, Erol; Yalcin, Oemer[Abstract Not Available]Öğe Osteosarcoma of the lumbar vertebra: case report and a review of the literature(Springer, 2009) Yalniz, Erol; Ozcan, Mert; Copuroglu, Cem; Memisoglu, Serdar; Yalcin, OemerClassic osteosarcoma (OS) is a highly malignant sarcoma with the production of osteoid matrix. The most common sites of origin are the metaphyseal regions of the distal femur, proximal tibia, and proximal humerus, although the tumor can develop in any bone. Flat bone involvement is very rare (8%). Vertebral involvement is also very rare with 2-4% of all cases. In this report, we presented a 27-year-old woman with OS of the fourth lumbar vertebra. She was treated with surgical debulking and posterior enstrumentation, followed by radiotherapy and chemotherapy. She is now in the 15th year postoperatively and still alive without any neurological impairment. This case has the longest survival reported in the literature with primary vertebral osteosarcoma.Öğe Preventive effects of curcumin on different aspiration material-induced lung injury in rats(Springer, 2009) Guzel, Ahmet; Kanter, Mehmet; Aksu, Burhan; Basaran, Umit Nusret; Yalcin, Oemer; Guzel, Aygul; Uzun, HafiseWe have studied whether curcumin protects different pulmonary aspiration material-induced lung injury in rats. The experiments were designed in 60 Sprague-Dawley rats, randomly allotted into one of six groups (n = 10): normal saline (NS, control), enteral formula (Biosorb Energy Plus, BIO), hydrochloric acid (HCl), NS + curcumin-treated, BIO + curcumin-treated, and HCl + curcumin-treated. NS, BIO, HCl were injected in to the lungs. The rats received curcumin twice daily only for 7 days. Seven days later, both lungs in all groups were examined histopathologically, immunohistochemically, and biochemically. Histopathologic examination was performed according to the presence of peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation. Immunohistochemical assessments were examined for the activity of inducible nitric oxide synthase (iNOS) and the expression of surfactant protein D (SP-D). Malondialdehyde (MDA), hydroxyproline (HP), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity were measured in the lung tissue. Our findings show that curcumin inhibits the inflammatory response reducing significantly (P < 0.05) all histopathological parameters in different pulmonary aspiration models. Pulmonary aspiration significantly increased the tissue HP content, MDA levels and decreased the antioxidant enzyme (SOD, GSH-Px) activities. Curcumin treatment significantly decreased the elevated tissue HP content, and MDA levels and prevented inhibition of SOD, and GSH-Px enzymes in the tissues. Furthermore, our data suggest that there is a significant reduction in the activity of iNOS and a rise in the expression of SP-D in lung tissue of different pulmonary aspiration models with curcumin therapy. Our findings support the use of curcumin as a potential therapeutic agent in acute lung injury.
